Polymorphic Variants rs13155212 (T/C) and rs7704267 (G/C) in the AGGF1 Gene and Risk of Varicose Veins of the Lower Extremities in the Population of Ethnic Russians
- Авторы: Shadrina A.S.1,2, Smetanina M.A.1, Sevost’ianova K.S.1, Sokolova E.A.1,2, Shevela A.I.1, Selivestrov E.I.3, Demekhova M.Y.4, Shonov O.A.4, Ilyukhin E.A.4, Voronina E.N.1,2, Zolotukhin I.A.3, Kirienko A.I.3, Filipenko M.L.1,2
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Учреждения:
- Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Clinic Medalp
- Выпуск: Том 161, № 5 (2016)
- Страницы: 698-702
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237686
- DOI: https://doi.org/10.1007/s10517-016-3488-x
- ID: 237686
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Аннотация
We analyzed associations between single nucleotide polymorphisms (SNP) rs13155212 and rs7704267 in the AGGF1 gene (angiogenic factor with G patch and FHA domains 1) and the risk of risk of varicose veins of the legs in ethnic Russians. Frequencies of alleles, genotypes, and haplotypes were estimated in the sample of patients with this disease (474 patients) and in the control group of participants (478 volunteers) without a history of chronic venous disease. None of the studied polymorphisms was associated with the risk of this pathology. The whole AGGF1 gene sequence lies in a single block of high linkage disequilibrium, and both studied polymorphic variants are representative of all other SNP within this region. From these results, a conclusion was made that AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians, or its contribution is low and can be revealed only after analysis of larger cohorts.
Об авторах
A. Shadrina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Автор, ответственный за переписку.
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk; Novosibirsk
M. Smetanina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk
K. Sevost’ianova
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk
E. Sokolova
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk; Novosibirsk
A. Shevela
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk
E. Selivestrov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: weiner.alexserg@gmail.com
Россия, Moscow
M. Demekhova
Clinic Medalp
Email: weiner.alexserg@gmail.com
Россия, St. Petersburg
O. Shonov
Clinic Medalp
Email: weiner.alexserg@gmail.com
Россия, St. Petersburg
E. Ilyukhin
Clinic Medalp
Email: weiner.alexserg@gmail.com
Россия, St. Petersburg
E. Voronina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk; Novosibirsk
I. Zolotukhin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: weiner.alexserg@gmail.com
Россия, Moscow
A. Kirienko
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: weiner.alexserg@gmail.com
Россия, Moscow
M. Filipenko
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: weiner.alexserg@gmail.com
Россия, Novosibirsk; Novosibirsk
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