Email this article Polymorphic Variants rs13155212 (T/C) and rs7704267 (G/C) in the AGGF1 Gene and Risk of Varicose Veins of the Lower Extremities in the Population of Ethnic Russians
- Authors: Shadrina A.S.1,2, Smetanina M.A.1, Sevost’ianova K.S.1, Sokolova E.A.1,2, Shevela A.I.1, Selivestrov E.I.3, Demekhova M.Y.4, Shonov O.A.4, Ilyukhin E.A.4, Voronina E.N.1,2, Zolotukhin I.A.3, Kirienko A.I.3, Filipenko M.L.1,2
-
Affiliations:
- Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Clinic Medalp
- Issue: Vol 161, No 5 (2016)
- Pages: 698-702
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237686
- DOI: https://doi.org/10.1007/s10517-016-3488-x
- ID: 237686
Cite item
Open Access
Access granted
Subscription Access
Abstract
We analyzed associations between single nucleotide polymorphisms (SNP) rs13155212 and rs7704267 in the AGGF1 gene (angiogenic factor with G patch and FHA domains 1) and the risk of risk of varicose veins of the legs in ethnic Russians. Frequencies of alleles, genotypes, and haplotypes were estimated in the sample of patients with this disease (474 patients) and in the control group of participants (478 volunteers) without a history of chronic venous disease. None of the studied polymorphisms was associated with the risk of this pathology. The whole AGGF1 gene sequence lies in a single block of high linkage disequilibrium, and both studied polymorphic variants are representative of all other SNP within this region. From these results, a conclusion was made that AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians, or its contribution is low and can be revealed only after analysis of larger cohorts.
About the authors
A. S. Shadrina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Author for correspondence.
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk; Novosibirsk
M. A. Smetanina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk
K. S. Sevost’ianova
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk
E. A. Sokolova
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk; Novosibirsk
A. I. Shevela
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk
E. I. Selivestrov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: weiner.alexserg@gmail.com
Russian Federation, Moscow
M. Yu. Demekhova
Clinic Medalp
Email: weiner.alexserg@gmail.com
Russian Federation, St. Petersburg
O. A. Shonov
Clinic Medalp
Email: weiner.alexserg@gmail.com
Russian Federation, St. Petersburg
E. A. Ilyukhin
Clinic Medalp
Email: weiner.alexserg@gmail.com
Russian Federation, St. Petersburg
E. N. Voronina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk; Novosibirsk
I. A. Zolotukhin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: weiner.alexserg@gmail.com
Russian Federation, Moscow
A. I. Kirienko
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: weiner.alexserg@gmail.com
Russian Federation, Moscow
M. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: weiner.alexserg@gmail.com
Russian Federation, Novosibirsk; Novosibirsk
