Biocompatibility of Experimental Polymeric Tracheal Matrices

M. V. Kiselevskii; I. O. Chikileva; R. Ya. Vlasenko; S. M. Sitdikova; T. Kh. Tenchurin; V. G. Mamagulashvili; A. D. Shepelev; T. A. Grigoriev; S. N. Chvalun

doi:10.1007/s10517-016-3455-6

Biocompatibility of Experimental Polymeric Tracheal Matrices

Authors: Kiselevskii M.V.¹, Chikileva I.O.¹, Vlasenko R.Y.¹, Sitdikova S.M.¹, Tenchurin T.K.², Mamagulashvili V.G.², Shepelev A.D.², Grigoriev T.A.², Chvalun S.N.²
Affiliations:
1. N. N. Blokhin Russian Cancer Research Center
2. National Research Center Kurchatov Institute
Issue: Vol 161, No 4 (2016)
Pages: 538-541
Section: Biotechnologies
URL: https://journals.rcsi.science/0007-4888/article/view/237576
DOI: https://doi.org/10.1007/s10517-016-3455-6
ID: 237576

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Abstract

Biocompatibility of a new tracheal matrix is studied. The new matrix is based on polymeric ultra-fiber material colonized by mesenchymal multipotent stromal cells. The experiments demonstrate cytoconductivity of the synthetic matrices and no signs of their degradation within 2 months after their implantation to recipient mice. These data suggest further studies of the synthetic tracheal matrices on large laboratory animals.