Email this article Effect of Aluminum, Iron, and Zinc Ions on the Assembly of Microtubules from Brain Microtubule Proteins
- Authors: Shevtsov P.N.1, Shevtsova E.F.1, Burbaeva G.S.2
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Affiliations:
- Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
- Laboratory of Neurochemistry, Research Center of Mental Health, Moscow, Institute of Physiologically Active Substances, Russian Academy of Sciences
- Issue: Vol 161, No 4 (2016)
- Pages: 451-455
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237511
- DOI: https://doi.org/10.1007/s10517-016-3436-9
- ID: 237511
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Abstract
Al3+, Fe3+, and Zn2+ ions can disturb microtubule assembly from tubulin and microtubuleassociated proteins in rat brain. The main structural forms of these microtubules are rings and tangled bundles. These structures are formed only in the presence of Al3+ and Fe3+ ions. Therefore, Zn2+ ions can be excluded from possible causes of structural abnormalities in microtubules during Alzheimer’s disease. Al3+ ions are the most probable etiological cause of Alzheimer’s disease. The concentration of Al3+ ions affecting the structure of microtubules is one order of magnitude lower than that of Fe3+ ions (10 and 100 μM, respectively), which corresponds to their brain concentration reported in Alzheimer’s disease.
About the authors
P. N. Shevtsov
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Author for correspondence.
Email: shevt@dio.ru
Russian Federation, Chernogolovka, Moscow Region
E. F. Shevtsova
Laboratory of Biomolecular Screening, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: shevt@dio.ru
Russian Federation, Chernogolovka, Moscow Region
G. Sh. Burbaeva
Laboratory of Neurochemistry, Research Center of Mental Health, Moscow, Institute of Physiologically Active Substances, Russian Academy of Sciences
Email: shevt@dio.ru
Russian Federation, Chernogolovka, Moscow Region
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