Email this article Relationship between the Size of Magnetic Nanoparticles and Efficiency of MRT Imaging of Cerebral Glioma in Rats
- Authors: Semkina A.S.1, Abakumov M.A.1, Abakumov A.M.2, Nukolova N.V.3, Chekhonin V.P.1,3
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Affiliations:
- Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University
- Electron Microscopy for Materials Science (EMAT), University of Antwerp
- V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, the Ministry of Health of the Russian Federation
- Issue: Vol 161, No 2 (2016)
- Pages: 292-295
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/237346
- DOI: https://doi.org/10.1007/s10517-016-3398-y
- ID: 237346
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Abstract
BSA-coated Fe3O4 nanoparticles with different hydrodynamic diameters (36±4 and 85±10 nm) were synthesized, zeta potential and T2 relaxivity were determined, and their morphology was studied by transmission electron microscopy. Studies on rats with experimental glioma C6 showed that smaller nanoparticles more effectively accumulated in the tumor and circulated longer in brain vessels. Optimization of the hydrodynamic diameter improves the efficiency of MRT contrast agent.
About the authors
A. S. Semkina
Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University
Author for correspondence.
Email: alevtina.semkina@gmail.com
Russian Federation, Moscow
M. A. Abakumov
Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University
Email: alevtina.semkina@gmail.com
Russian Federation, Moscow
A. M. Abakumov
Electron Microscopy for Materials Science (EMAT), University of Antwerp
Email: alevtina.semkina@gmail.com
Belgium, Groenenborgerlaan, Antwerp
N. V. Nukolova
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, the Ministry of Health of the Russian Federation
Email: alevtina.semkina@gmail.com
Russian Federation, Moscow
V. P. Chekhonin
Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University; V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, the Ministry of Health of the Russian Federation
Email: alevtina.semkina@gmail.com
Russian Federation, Moscow; Moscow
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