Email this article Radioprotective and Apoptotic Properties of a Combination of α-Tocopherol Acetate and Ascorbic Acid
- Authors: Vasil’eva I.N.1,2, Bespalov V.G.1,2, Baranenko D.A.2
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Affiliations:
- Laboratory of Chemoprevention of Cancer and Oncopharmacology, N. N. Petrov Institute of Oncology, Ministry of the Healthcare of the Russian Federation
- International Scientific Center Biotechnologies of the Third Millennium, University of Informational Technologies, Mechanics and Optics
- Issue: Vol 161, No 2 (2016)
- Pages: 248-251
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237304
- DOI: https://doi.org/10.1007/s10517-016-3388-0
- ID: 237304
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Abstract
We studied radioprotective and apoptotic properties of a combination of α-tocopherol acetate and ascorbic acid. α-Tocopherol acetate (10 mg/kg body weight) or ascorbic acid (20 mg/kg) or combination of these agents in the same doses was orally administered to male rats at various terms before and after single whole-body exposure to γ-irradiation in the doses of 2 and 8 Gy. Irradiation increased the frequency of chromosome aberrations in bone marrow cells and plasma level of low-molecular-weight DNA. Vitamin combination administered before or after irradiation significantly reduced the frequency of chromosome aberrations by 2-2.5 times. Administration of this combination 10 min before irradiation 1.5-fold increased the content of low-molecular-weight DNA in blood plasma in comparison with the control animals exposed to radiation. The combination of α-tocopherol acetate and ascorbic acid produced radioprotective effects and enhanced apoptosis in irradiated cells.
About the authors
I. N. Vasil’eva
Laboratory of Chemoprevention of Cancer and Oncopharmacology, N. N. Petrov Institute of Oncology, Ministry of the Healthcare of the Russian Federation; International Scientific Center Biotechnologies of the Third Millennium, University of Informational Technologies, Mechanics and Optics
Author for correspondence.
Email: iravasilyeva@hotmail.com
Russian Federation, St. Petersburg; St. Petersburg
V. G. Bespalov
Laboratory of Chemoprevention of Cancer and Oncopharmacology, N. N. Petrov Institute of Oncology, Ministry of the Healthcare of the Russian Federation; International Scientific Center Biotechnologies of the Third Millennium, University of Informational Technologies, Mechanics and Optics
Email: iravasilyeva@hotmail.com
Russian Federation, St. Petersburg; St. Petersburg
D. A. Baranenko
International Scientific Center Biotechnologies of the Third Millennium, University of Informational Technologies, Mechanics and Optics
Email: iravasilyeva@hotmail.com
Russian Federation, St. Petersburg
