Effect of Proline-Containing Oligopeptides PGP and RGP on Proliferative and Protein-Synthesizing Activity of Cultured Pulmonary Fibroblasts under Conditions of Oxidative Stress
- Authors: Tolstenok I.V.1, Fleishman M.Y.1, Sazonova E.N.1, Lebed’ko O.A.1,2, Maltseva I.M.3, Myasoedov N.F.4, Timoshin S.S.1
-
Affiliations:
- Central Research Laboratory, Far-Eastern State Medical University
- Research Institute of Maternal and Child Health Care, Khabarovsk Branch of Far-Eastern Research Center of Physiology and Pathology of Respiration
- Biarritz Medical Esthetic Center
- Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 161, No 1 (2016)
- Pages: 184-186
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/237254
- DOI: https://doi.org/10.1007/s10517-016-3372-8
- ID: 237254
Cite item
Abstract
We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced intensive oxidative stress accompanied by suppression of protein-synthesizing function. When hydrogen peroxide was added to the culture containing the test peptides, correction of the oxidative status was observed accompanied by activation of DNA-synthesizing activity and inhibition of lucigenin-dependent chemiluminescence.
About the authors
I. V. Tolstenok
Central Research Laboratory, Far-Eastern State Medical University
Email: marfl@yandex.ru
Russian Federation, Khabarovsk
M. Yu. Fleishman
Central Research Laboratory, Far-Eastern State Medical University
Author for correspondence.
Email: marfl@yandex.ru
Russian Federation, Khabarovsk
E. N. Sazonova
Central Research Laboratory, Far-Eastern State Medical University
Email: marfl@yandex.ru
Russian Federation, Khabarovsk
O. A. Lebed’ko
Central Research Laboratory, Far-Eastern State Medical University; Research Institute of Maternal and Child Health Care, Khabarovsk Branch of Far-Eastern Research Center of Physiology and Pathology of Respiration
Email: marfl@yandex.ru
Russian Federation, Khabarovsk; Khabarovsk
I. M. Maltseva
Biarritz Medical Esthetic Center
Email: marfl@yandex.ru
Russian Federation, Khabarovsk
N. F. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: marfl@yandex.ru
Russian Federation, Moscow
S. S. Timoshin
Central Research Laboratory, Far-Eastern State Medical University
Email: marfl@yandex.ru
Russian Federation, Khabarovsk