Email this article Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro
- Authors: Lin’kova N.S.1,2,3, Drobintseva A.O.4, Orlova O.A.1, Kuznetsova E.P.3, Polyakova V.O.1,4, Kvetnoy I.M.1,4, Khavinson V.K.1,2,5
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Peter the Great St. Petersburg Polytechnical University
- D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
- I. I. Mechnikov North-Western State Medical University
- Issue: Vol 161, No 1 (2016)
- Pages: 175-178
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/237247
- DOI: https://doi.org/10.1007/s10517-016-3370-x
- ID: 237247
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Abstract
The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging. Peptides AED and AEDG suppressed caspase-dependent apoptosis that increases during aging of cell cultures.
About the authors
N. S. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnical University
Author for correspondence.
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
A. O. Drobintseva
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
O. A. Orlova
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
E. P. Kuznetsova
Peter the Great St. Petersburg Polytechnical University
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
V. O. Polyakova
St. Petersburg Institute of Bioregulation and Gerontology; D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
I. M. Kvetnoy
St. Petersburg Institute of Bioregulation and Gerontology; D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; I. I. Mechnikov North-Western State Medical University
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
