Multiwalled Carbon Nanotubules Induce Pathological Changes in the Digestive Organs of Mice
- Authors: Masyutin A.G.1, Erokhina M.V.1, Sychevskaya K.A.1, Gusev A.A.2, Vasyukova I.A.2, Tkachev A.G.3, Smirnova E.A.1, Onishchenko G.E.1
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Affiliations:
- M. V. Lomonosov Moscow State University
- Nanotechnologies and Nanomaterials Research and Education Center, G. R. Derzhavin Tambov State University
- NanoTechCenter
- Issue: Vol 161, No 1 (2016)
- Pages: 125-130
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237188
- DOI: https://doi.org/10.1007/s10517-016-3361-y
- ID: 237188
Cite item
Abstract
We studied the effects of regular long-term exposure to industrial nanomaterial based on multiwalled carbon nanotubules on the digestive system of mice. Nanomaterial in a concentration of 30 mg/kg was administered with drinking water over 30 days. Tissue specimens from the small intestine and liver were studied by light and electron microscopy. Multiwalled carbon nanotubules caused multiple necrotic foci in the small intestine and mixed parenchymatous degeneration in the liver. These findings suggested that multiwalled carbon nanotubules entering the digestive tract damaged intestinal villi, presumably via mechanical damage to enterocytes. It seems that multiwalled carbon nanotubules could cause degeneration indirectly, by triggering inflammatory reactions and ROS generation.
About the authors
A. G. Masyutin
M. V. Lomonosov Moscow State University
Author for correspondence.
Email: imber.acidis@gmail.com
Russian Federation, Moscow
M. V. Erokhina
M. V. Lomonosov Moscow State University
Email: imber.acidis@gmail.com
Russian Federation, Moscow
K. A. Sychevskaya
M. V. Lomonosov Moscow State University
Email: imber.acidis@gmail.com
Russian Federation, Moscow
A. A. Gusev
Nanotechnologies and Nanomaterials Research and Education Center, G. R. Derzhavin Tambov State University
Email: imber.acidis@gmail.com
Russian Federation, Tambov
I. A. Vasyukova
Nanotechnologies and Nanomaterials Research and Education Center, G. R. Derzhavin Tambov State University
Email: imber.acidis@gmail.com
Russian Federation, Tambov
A. G. Tkachev
NanoTechCenter
Email: imber.acidis@gmail.com
Russian Federation, Tambov
E. A. Smirnova
M. V. Lomonosov Moscow State University
Email: imber.acidis@gmail.com
Russian Federation, Moscow
G. E. Onishchenko
M. V. Lomonosov Moscow State University
Email: imber.acidis@gmail.com
Russian Federation, Moscow