Analysis of the Relationship between Antioxidant Enzyme Gene Polymorphisms and Their Activity in Post-Traumatic Gonarthrosis
- Authors: Vnukov V.V.1, Panina S.B.1, Milyutina N.P.1, Krolevets I.V.2, Zabrodin M.A.2
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Affiliations:
- Southern Federal University
- Rostov State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 1 (2016)
- Pages: 75-78
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/237115
- DOI: https://doi.org/10.1007/s10517-016-3349-7
- ID: 237115
Cite item
Abstract
Analysis of polymorphisms of genes encoding antioxidant enzymes SOD1 (G7958A), SOD2 (T58C), CAT (C-262T), and GSTP1 (Ile105Val) in 93 patients with post-traumatic gonarthrosis showed that GSTP1 Ile105Val polymorphism is often associated with heterozygous mutation in catalase gene CAT C-262T. In gonarthrosis, catalase activity in peripheral blood mononuclear cells in patients with CT genotype of the C-262T locus of CAT gene more than 2-fold surpassed that in CC genotype and more than 50% surpassed the normal. Changes in the balance of activity of antioxidant enzymes can affect viability of mononuclear cells.
About the authors
V. V. Vnukov
Southern Federal University
Email: tailana703@gmail.com
Russian Federation, Rostov-on-Don
S. B. Panina
Southern Federal University
Author for correspondence.
Email: tailana703@gmail.com
Russian Federation, Rostov-on-Don
N. P. Milyutina
Southern Federal University
Email: tailana703@gmail.com
Russian Federation, Rostov-on-Don
I. V. Krolevets
Rostov State Medical University, Ministry of Health of the Russian Federation
Email: tailana703@gmail.com
Russian Federation, Rostov-on-Don
M. A. Zabrodin
Rostov State Medical University, Ministry of Health of the Russian Federation
Email: tailana703@gmail.com
Russian Federation, Rostov-on-Don