Peptidyl Aldehyde Specifically Interacts with Immunosubunit β1i Proteasome: In Vitro and In Vivo Effects
- Authors: Kuzina E.S.1, Kudriaeva A.A.1, Maltseva D.V.2, Belogurov A.A.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- BioClinicum Research and Development Center
- Issue: Vol 161, No 1 (2016)
- Pages: 69-71
- Section: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237107
- DOI: https://doi.org/10.1007/s10517-016-3347-9
- ID: 237107
Cite item
Abstract
We studied the effect of β1i-specific peptidyl aldehyde IPSI-001 on proteasome from mammalian cells. In concentrations <1 μM, this agent effectively suppressed immunoproteasome, but only slightly reduced chymotrypsin-like activity of constitutive proteasome. Intraperitoneal administration of this inhibitor to C3H/He mice in a dose of 100 mg/kg induced no significant physiological or behavioral changes, which attested to its considerable therapeutic potential in the treatment of autoimmune neurodegenerative pathologies.
About the authors
E. S. Kuzina
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: belogurov@mx.ibch.ru
Russian Federation, Moscow
A. A. Kudriaeva
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: belogurov@mx.ibch.ru
Russian Federation, Moscow
D. V. Maltseva
BioClinicum Research and Development Center
Email: belogurov@mx.ibch.ru
Russian Federation, Moscow
A. A. Belogurov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: belogurov@mx.ibch.ru
Russian Federation, Moscow