Antiproliferative Potential of Officinal Forms and Nanoparticles of Lithium Salts

A. P. Lykov; O. V. Poveshchenko; N. A. Bondarenko; N. P. Bogatova; O. P. Makarova; V. I. Konenkov

doi:10.1007/s10517-016-3320-7

Antiproliferative Potential of Officinal Forms and Nanoparticles of Lithium Salts

Authors: Lykov A.P.¹, Poveshchenko O.V.¹, Bondarenko N.A.¹, Bogatova N.P.¹, Makarova O.P.¹, Konenkov V.I.¹
Affiliations:
1. Research Institute of Clinical and Experimental Lymphology
Issue: Vol 160, No 6 (2016)
Pages: 827-830
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/236980
DOI: https://doi.org/10.1007/s10517-016-3320-7
ID: 236980

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Abstract

We studied the effect of officinal forms and nanoparticles of lithium carbonate and lithium citrate on proliferative activity of hepatoma-29 cells. Lithium carbonate nanoparticles suppressed proliferation of hepatoma-29 cells in lower concentrations than officinal form of this salt. The antiproliferative effect of lithium salts i activation of apoptosis and arrest of hepatoma-29 cells in the G₂/M phase of the cell cycle.