Email this article Detection of Gold Nanoparticles in Rat Organs by Transmission Electron Microscopy
- Authors: Platonova T.A.1, Pridvorova S.M.1, Zherdev A.V.1, Gmoshinskii I.V.2, Vasilevskaya L.S.2, Dzantiev B.B.1
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Affiliations:
- A. N. Bach Institute of Biochemistry, Russian Academy of Sciences
- Research Institute of Nutrition
- Issue: Vol 160, No 6 (2016)
- Pages: 817-822
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236973
- DOI: https://doi.org/10.1007/s10517-016-3318-1
- ID: 236973
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Abstract
The effects of water-dispersed gold nanoparticles (8.0±0.9 nm in diameter) on the rat small intestinal mucosa and Peyer plaques, liver, and spleen were studied by electron microscopy. Water-dispersed gold nanoparticles injected into isolated intestinal loop not only accumulated in the small intestinal mucosa and Peyer plaques, but also penetrated into other organs, e.g. liver and spleen. Ultrastructural changes in the cells (hyperplasia of endoplasmic reticulum) were detected in the studied organs.
About the authors
T. A. Platonova
A. N. Bach Institute of Biochemistry, Russian Academy of Sciences
Email: dzantiev@inbi.ras.ru
Russian Federation, Moscow
S. M. Pridvorova
A. N. Bach Institute of Biochemistry, Russian Academy of Sciences
Email: dzantiev@inbi.ras.ru
Russian Federation, Moscow
A. V. Zherdev
A. N. Bach Institute of Biochemistry, Russian Academy of Sciences
Email: dzantiev@inbi.ras.ru
Russian Federation, Moscow
I. V. Gmoshinskii
Research Institute of Nutrition
Email: dzantiev@inbi.ras.ru
Russian Federation, Moscow
L. S. Vasilevskaya
Research Institute of Nutrition
Email: dzantiev@inbi.ras.ru
Russian Federation, Moscow
B. B. Dzantiev
A. N. Bach Institute of Biochemistry, Russian Academy of Sciences
Author for correspondence.
Email: dzantiev@inbi.ras.ru
Russian Federation, Moscow
