Insulin-Like Growth Factors (IGF) and IGF-Binding Proteins (IGFBP) in the Serum of Patients with Ovarian Tumors
- Authors: Gershtein E.S.1, Isaeva E.R.2, Kushlinsky D.N.1, Korotkova E.A.2, Ermilova V.D.2, Laktionov K.P.2, Adamyan L.V.1
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Affiliations:
- V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
- N. N. Blokhin Russian Cancer Research Center
- Issue: Vol 160, No 6 (2016)
- Pages: 814-816
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236969
- DOI: https://doi.org/10.1007/s10517-016-3317-2
- ID: 236969
Cite item
Abstract
IGF-1, IGF-2, and IGFBP-1,2,3 were assayed in blood serum of patients with malignant ovarian tumors (n=44), borderline ovarian tumors (n=11), and benign ovarian tumors (n=12) as well as in healthy women (n=33). In blood serum of patients with malignant ovarian tumors, the level of IGF-1 was lower and IGFBP-1 was higher than in other groups. In patients with malignant and borderline ovarian tumors, the level of IGFBP-2 was higher than in healthy women and in patients with benign ovarian tumors. There was no correlation between most examined parameters and the clinical and morphological peculiarities of ovarian tumors. The study revealed IGF/IGFBP imbalance in patients with malignant ovarian tumor and showed that IGFBP-2 proved to be a potential diagnostic serological marker w with 90% sensitivity and 90% specificity.
About the authors
E. S. Gershtein
V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
E. R. Isaeva
N. N. Blokhin Russian Cancer Research Center
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
D. N. Kushlinsky
V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
E. A. Korotkova
N. N. Blokhin Russian Cancer Research Center
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
V. D. Ermilova
N. N. Blokhin Russian Cancer Research Center
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
K. P. Laktionov
N. N. Blokhin Russian Cancer Research Center
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
L. V. Adamyan
V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: biochimia@mtu-net.ru
Russian Federation, Moscow
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