Genetic Instability in Locus rs5498 E469K (A/G) of ICAM-1 Gene in Patients with Colorectal Cancer and Breast Cancer
- Authors: Novikov V.V.1, Shumilova S.V.1, Novikov D.V.1, Kalugin A.V.1, Fomina S.G.1, Karaulov A.V.1,2
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Affiliations:
- National Research University, N. I. Lobachevsky Nizhny Novgorod University
- I. M. Sechenov First Moscow State Medical University
- Issue: Vol 160, No 6 (2016)
- Pages: 811-813
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236962
- DOI: https://doi.org/10.1007/s10517-016-3316-3
- ID: 236962
Cite item
Abstract
Single-nucleotide polymorphism rs5498 E469K (A/G) in ICAM-1 gene modulates functional activity of this protein and is associated with the risk of some diseases. Tumor cell rs5498 E469K (A/G) genotypes were compared with genotypes of patients with colorectal and breast cancer, residents of the Nizhniy Novgorod region. Specimens of peripheral blood and tumor foci from patients with colorectal and breast cancer and peripheral blood specimens from normal subjects were analyzed. The frequency of genotypes of single-nucleotide rs5498 E469K (A/G) sequence in the Nizhny Novgorod population coincide with the frequency of genotypes characteristic of residents of Germany. Comparison of genotypes of peripheral blood and tumor cells from patients with colorectal and breast cancer showed loss of cancer cell heterozygosity. The frequency of heterozygosity loss increases with colorectal cancer progress from one stage to another.
About the authors
V. V. Novikov
National Research University, N. I. Lobachevsky Nizhny Novgorod University
Email: drkaraulov@mail.ru
Russian Federation, Nizhny Novgorod
S. V. Shumilova
National Research University, N. I. Lobachevsky Nizhny Novgorod University
Email: drkaraulov@mail.ru
Russian Federation, Nizhny Novgorod
D. V. Novikov
National Research University, N. I. Lobachevsky Nizhny Novgorod University
Email: drkaraulov@mail.ru
Russian Federation, Nizhny Novgorod
A. V. Kalugin
National Research University, N. I. Lobachevsky Nizhny Novgorod University
Email: drkaraulov@mail.ru
Russian Federation, Nizhny Novgorod
S. G. Fomina
National Research University, N. I. Lobachevsky Nizhny Novgorod University
Email: drkaraulov@mail.ru
Russian Federation, Nizhny Novgorod
A. V. Karaulov
National Research University, N. I. Lobachevsky Nizhny Novgorod University; I. M. Sechenov First Moscow State Medical University
Author for correspondence.
Email: drkaraulov@mail.ru
Russian Federation, Nizhny Novgorod; Moscow
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