Effects of Hypothermia and Self-Warming on Activity of Ca2+-Dependent Neutral Proteases in Tissues of Ground Squirrels and Rats


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Abstract

Effects of hypothermia and subsequent self-warming on activity of Ca2+-dependent neutral proteases were studied in tissues of ground squirrels and rats. Moderate hypothermia did not significantly change activity of Ca2+-dependent neutral proteases in the analyzed tissues of ground squirrels, but reduced protease activity in rat heart. Severe hypothermia reduced enzyme activity in the analyzed tissues of rats and ground squirrels. Differences in activity of Ca2+-dependent neutral proteases after long-term hypothermia and subsequent self-warming were found only in the heart.

About the authors

P. M. Nurmagomedova

Department of Biochemistry and Biophysics, Dagestan State University, Ministry of Education and Science of the Russian Federation

Author for correspondence.
Email: parizat1949@bk.ru
Russian Federation, Dagestan

E. Z. Emirbekov

Department of Physical and Chemical Biology, Affiliated Branch of the Southern Federal University, Ministry of Education and Science of the Russian Federation

Email: parizat1949@bk.ru
Russian Federation, Makhachkala, Republic of Dagestan

M. M. Abasova

Department of Biochemistry and Biophysics, Dagestan State University, Ministry of Education and Science of the Russian Federation

Email: parizat1949@bk.ru
Russian Federation, Dagestan

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