Effects of Hypobaric Hypoxia in Various Modes on Expression of Neurogenesis Marker NeuroD2 in the Dentate Gyrus of Rats Hippocampus
- Authors: Vetrovoi O.V.1, Rybnikova E.A.2, Glushchenko T.S.1, Samoilov M.O.1
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Affiliations:
- Laboratory of Regulation of Cerebral Neuron Functions
- Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 160, No 4 (2016)
- Pages: 510-513
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236761
- DOI: https://doi.org/10.1007/s10517-016-3209-5
- ID: 236761
Cite item
Abstract
The expression of neurogenesis marker – NeuroD2 transcription factor – in the hippocampal dentate gyrus was studied in rats exposed to severe destructive hypoxia, a single or three episodes of moderate hypobaric hypoxia, preconditioned severe hypoxia, and severe hypoxia followed by 3 sessions of postconditioning by moderate hypobaric hypoxia. All the studied hypoxic exposure modes led to an increase of NeuroD2 level. Three-fold moderate hypoxia per se and in the preconditioning mode (followed by exposure to severe hypoxia) produced most pronounced up-regulatory effect on NeuroD2 expression. The results indicated that stimulation of neurogenesis processes seemed to be one of the aspects of the neuroprotective effect of three-fold preconditioning moderate hypoxia, but not of hypoxic postconditioning.
About the authors
O. V. Vetrovoi
Laboratory of Regulation of Cerebral Neuron Functions
Author for correspondence.
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg
E. A. Rybnikova
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg
T. S. Glushchenko
Laboratory of Regulation of Cerebral Neuron Functions
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg
M. O. Samoilov
Laboratory of Regulation of Cerebral Neuron Functions
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg
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