Email this article Interleukin-1β Can Reduce Manifestations of Delayed Effects of Prolonged Exposure to Low-Intensity γ-Radiation
- Authors: Vorobyeva N.Y.1, Grekhova A.K.1, Trubitsina K.Y.2, Pchelka A.V.2, Rozhdestevenskiy L.M.2, Osipov A.N.2
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Affiliations:
- Laboratory of Radiation Biophysics, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- Issue: Vol 160, No 4 (2016)
- Pages: 470-473
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236738
- DOI: https://doi.org/10.1007/s10517-016-3199-3
- ID: 236738
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Abstract
We showed that injection of IL-1β (Betaleukin) in a dose of 3 μg/kg 22 h before prolonged (21 h) exposure to low-intensity (10 mGy/min) γ-radiation in a dose of 12.6 Gy reduced the number of double-strand DNA breaks in murine spleen cells to the control level in 4 months after exposure and the number of double-strand DNA breaks induced by additional acute irradiation in a dose of 6 Gy. The results suggest that IL-1β can improve the efficiency of systems reducing the number of double-strand DNA breaks in murine spleen cells at delayed terms after exposure to prolonged low-intensity radiation.
About the authors
N. Yu. Vorobyeva
Laboratory of Radiation Biophysics, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Author for correspondence.
Email: nuv.rad@mail.ru
Russian Federation, Moscow
A. K. Grekhova
Laboratory of Radiation Biophysics, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: nuv.rad@mail.ru
Russian Federation, Moscow
K. Yu. Trubitsina
Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: nuv.rad@mail.ru
Russian Federation, Moscow
A. V. Pchelka
Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: nuv.rad@mail.ru
Russian Federation, Moscow
L. M. Rozhdestevenskiy
Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: nuv.rad@mail.ru
Russian Federation, Moscow
A. N. Osipov
Laboratory of Radiation Pharmacology, A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
Email: nuv.rad@mail.ru
Russian Federation, Moscow
