Hepatocyte Suspension as a Biological Material for Extracorporeal Liver Support Systems

V. E. Ryabinin; E. E. Polevschikova; P. N. Popkov; S. A. Pushkarev; A. I. Sinitskii; A. A. Stasyuk; P. O. Platkovskii

doi:10.1007/s10527-017-9721-8

Hepatocyte Suspension as a Biological Material for Extracorporeal Liver Support Systems

Authors: Ryabinin V.E.¹, Polevschikova E.E.¹, Popkov P.N.¹, Pushkarev S.A.¹, Sinitskii A.I.¹, Stasyuk A.A.¹, Platkovskii P.O.¹
Affiliations:
1. South Ural State Medical University, Ministry of Health of the Russian Federation
Issue: Vol 51, No 4 (2017)
Pages: 234-238
Section: Article
URL: https://journals.rcsi.science/0006-3398/article/view/235128
DOI: https://doi.org/10.1007/s10527-017-9721-8
ID: 235128

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Abstract

Experimental in vitro studies have demonstrated the possibility of use and the efficiency of the hepatocyte suspension as a biological material for the elimination of toxic compounds and normalization of metabolic processes during plasma dialysis using a bioartificial liver device. The developed circuits and bioreactor devices provide optimal conditions for normal functioning of the rat hepatocyte suspension for several hours required for cell dialysis.