Results of FLASH Irradiation of Mice in vivo with High-Energy Protons
- Autores: Shemyakov A.1,2, Dyukina A.1, Zaichkina S.1, Agapov A.3, Mitsyn G.3, Shipulin K.3
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Afiliações:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Physical-Technical Center of the Physical Institute, Russian Academy of Sciences
- Joint Institute for Nuclear Research
- Edição: Volume 69, Nº 4 (2024)
- Páginas: 887-894
- Seção: Complex systems biophysics
- URL: https://journals.rcsi.science/0006-3029/article/view/264952
- DOI: https://doi.org/10.31857/S0006302924040197
- EDN: https://elibrary.ru/NFERGZ
- ID: 264952
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Sobre autores
A. Shemyakov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; Physical-Technical Center of the Physical Institute, Russian Academy of Sciences
Email: alshemyakov@yandex.ru
Pushchino, Russia; Protvino, Russia
A. Dyukina
Institute of Theoretical and Experimental Biophysics, Russian Academy of SciencesPushchino, Russia
S. Zaichkina
Institute of Theoretical and Experimental Biophysics, Russian Academy of SciencesPushchino, Russia
A. Agapov
Joint Institute for Nuclear ResearchDubna, Russia
G. Mitsyn
Joint Institute for Nuclear ResearchDubna, Russia
K. Shipulin
Joint Institute for Nuclear ResearchDubna, Russia
Bibliografia
- Diffenderfer E., Verginadis I., Kim M., Shoniyozov K., Velalopoulou A., Goia D., Putt M., Hagan S., Avery S., Teo K., Zou W., Lin A., Swisher-McClure S., Koch C., Kennedy A. R., Minn A., Maity A., Busch T. M., Dong L., Koumenis C., Metz J., and Cengel K. A. Design, implementation, and in vivo validation of a novel proton flash radiation therapy system. Int. J. Radiat. Oncol. Biol. Phys., 106 (2), 440–448 (2020). doi: 10.1016/j.ijrobp.2019.10.049
- Favaudon V., Caplier L., Monceau V., Pouzoulet F., Sayarath M., Fouillade C., Poupon M. F., Brito I., Hupe P., Bourhis J., Hall J., Fontaine J. J., and Vozenin M. C. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci. Transl. Med., 6 (245), 245ra93 (2014). doi: 10.1126/scitranslmed.3008973
- Soto L., Casey K., Wang J., Blaney A., Manjappa R., Breitkreutz D., Skinner L., Dutt S., Ko R., Bush K., Yu A., Melemenidis S., Strober S., Englemann E., Maxim P., Graves E., and Loo B. FLASH irradiation results in reduced severe skin toxicity compared to conventionaldose-rate irradiation. Radiat. Res., 194 (6), 618–624 (2020). doi: 10.1667/RADE-20-00090
- Spitz D., Buettner G., Petronek M., St-Aubin J., Flynn R., Waldron T., and Limoli C. An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. Radiother. Oncol., 139, 23–27 (2019). doi: 10.1016/j.radonc.2019.03.028
- Simmons D., Lartey F., Schuler E., Rafat M., King G., Kim A., Ko R., Semaan S., Gonzalez S., Jenkins M., Pradhan P., Shih Z., Wang J., von Eyben R., Graves E., Maxim P., Longo F., and Loo B. Jr. Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiother. Oncol., 139, 4–10 (2019). doi: 10.1016/j.radonc.2019.06.006
- Rama N., Saha T., Shukla S., Goda C., Milewski D., Mascia A., Vatner R., Sengupta D., Katsis A., Abel E., Girdhani S., Miyazaki M., Rodriguez A., Ku A., Dua R., Parry R., and Kalin T. Improved tumor control through t-cell infiltration modulated by ultra-high dose rate proton flash using a clinical pencil beam scanning proton system. Int. J. Radiat. Oncol. Biol. Phys., 105, S164–S165 (2019). doi: 10.1016/j.ijrobp.2019.06.187
- Агапов А. В., Грицкова Е. А., Густов С. А., Мицын Г. В., Молоканов А. Г., Хасенова И., Швидкий С. В. и Шипулин К. Н. Формирование высокоинтенсивного пучка протонов для исследования флэш-эффекта в лучевой терапии. Медицинская физика, 4, 29–39 (2023). doi: 10.52775/1810-200X-2023-100-4-29-39
- Директива 2010/63/eu Европейского парламента и Совета Европейского союза. URL.: https://ruslasa.ru/wp-content/uploads/2017/06/Directive_201063_rus.pdf (дата обращения: 12.03.2024 г.).
- Krupina K., Goginashvili A., and Cleveland D. Causes and consequences of micronuclei. Curr. Opin. Cell Biol., 70, 91–99 (2021). doi: 10.1016/j.ceb.2021.01.004.
- Hayashi M. The micronucleus test – most widely used in vivo genotoxicity test. Genes and Environ., 38, 18 (2016). doi: 10.1186/s41021-016-0044-x
- Балакин В., Розанова О., Смирнова Е., Белякова Т., Стрельникова Н., Смирнов А. и Шемяков А. Индукция роста солидной формы асцитной карциномы эрлиха у мышей после облучения протонами опухолевых клеток ex vivo. Докл. РАН. Науки о жизни. 511 (1), 360–364 (2023). doi: 10.31857/S2686738923600152
- Балакин В., Розанова О., Смирнова Е., Белякова Т., Шемяков А., Заичкина С., Сорокина С. и Дюкина А. Действие низких и средних доз тонкого сканирующего пучка протонов на органы кроветворения при тотальном облучении мышей. Докл. РАН. Науки о жизни. 494 (1), 458–462 (2020). doi: 10.31857/S2686738920050042.
- Lin B., Gao F., Yang Y., Wu D., Zhang Y., Feng G., Dai T., and Du X. FLASH radiotherapy: history and future. Front. Oncol., 11, 644400 (2021). doi: 10.3389/fonc.2021.644400.
- Hughes J. and Parsons J. FLASH radiotherapy: current knowledge and future insights using proton-beam therapy. Int. J. Mol. Sci., 21, 6492 (2020). doi: 10.3390/ijms21186492.
- Beyreuther E., Brand M., Hans S., Hideghety K., Karsch L., Lebmann E., Schurer M., Szabo E., and Pawelke J. Feasibility of proton FLASH effect tested by zebrafish embryo irradiation. Radiother. Oncol., 139, 46–50 (2019). doi: 10.1016/j.radonc.2019.06.024.
- Zhang Q., Cascio E., Li C., Yang Q., Gerweck L., Huang P., Gottschalk B., Flanz J., and Schuemann J. FLASH investigations using protons: design of delivery system, preclinical setup and confirmation of FLASH effect with protons in animal systems. Radiat. Res., 194 (6), 656–664 (2020). doi: 10.1667/RADE-20-00068.1.