Enviar artigo por via de e-mail Therapeutic effects of high-dose inhaled nitric oxide gas against post-covid syndrome, diabetes or AIDS
- Autores: Vanin A.1, Pekshev A.2, Pechyonkin E.3, Vagapov A.2, Sharapov N.2
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Afiliações:
- N.N. Semenov Federal Research Center for Chemical Physics
- N.E. Bauman Moscow State Technical University
- Stavropol State Medical University
- Edição: Volume 68, Nº 1 (2023)
- Páginas: 142-149
- Seção: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/144414
- DOI: https://doi.org/10.31857/S0006302923010167
- EDN: https://elibrary.ru/OBGWMC
- ID: 144414
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Resumo
A therapeutic effect of high-dose nitric oxide gas inhalation (more than 1000 ppm) on patients with post-COVID syndrome, diabetes or AIDS is shown. It has been proposed that nitrosonium cations (NO+), derivatives of nitric oxide gas, the emergence of which in the blood or organ tissues of patients is related to disproportion reaction of NO molecules, forming a co-ordinate bond with the Fe2+ion, carried by transferrin or entered into the labile (free) iron pool may act as a therapeutic agent. It is quite probable that treatment of HIV infection (as well as the earlier revealed effect of NO gas on the patients with COVID-19) could be provided by the effects of S-nitrosylation of NO+ cations on thiol groups of viral proteases and host proteins. A beneficial effect of NO+ cations which emerged in the reaction of NO gas molecules in patients with post-COVID syndrome or diabetes can be also associated with an inhibitory effect of these cations on the thiol-containig proteins that are involved in apoptosis.
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Sobre autores
A. Vanin
N.N. Semenov Federal Research Center for Chemical Physics
Email: vanin.dnic@gmail.com
Moscow, Russia
A. Pekshev
N.E. Bauman Moscow State Technical UniversityMoscow, Russia
E. Pechyonkin
Stavropol State Medical UniversityStavropol, Russia
A. Vagapov
N.E. Bauman Moscow State Technical UniversityMoscow, Russia
N. Sharapov
N.E. Bauman Moscow State Technical UniversityMoscow, Russia
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