Nitrosonium Cation as a Nitroprusside Constituent Determining Its Cytotoxicity

Мұқаба

Дәйексөз келтіру

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

It has been demonstrated that nitrosonium cation (NO+) transformation as a constituent of sodium nitroprusside into NO molecule under action of sodium dithionite as a strong reducer did not result in full supression of cytotoxic activity of nitroprusside solution as NO+ donor on the culture of MCF-7 tumour cells. As a matter of fact, NO molecules and Fe2+ ions released from SNP at this conditions formed dinitrosyl iron complexes with thiol-containing ligands (thiol-containing proteins or thiosulphate anions appeared from decomposed dithionite).The half of nitrosyl ligands in the complexes represented also as in nitroprusside in cytotoxic NO+ form. Nevertheless because the amount of dinitrosyl iron complexes was three times less than that of initial nitroprusside the cytotoxic effect of nitroprusside solution as NO+ donors sharply decreased under action of dithionite on nitroprusside.

Авторлар туралы

A. Vanin

Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences

Email: vanin.dnic@gmail.com
Moscow, Russia

V. Tronov

Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences

Moscow, Russia

N. Trifonova

Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences

Moscow, Russia

E. Nekrasova

N.M. Emanuel Institute for Biochemical Physics, Russian Academy of Sciences

Moscow, Russia

V. Mikoyan

Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences

Moscow, Russia

N. Tkachev

Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences

Moscow, Russia

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