Email this article Stability of Hypotensive Activity in Freeze-Dried Preparations of Dinitrozyl Iron Complexes with Glutathione (“Oxacom”) throughout the Period of Storage for 15 Years at Ambient Temperature
- Authors: Vanin A.F1, Abramov A.A2, Timoshin A.A2, Lakomkin V.L2, Tkachev N.A1
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Affiliations:
- N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
- E.I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- Issue: Vol 69, No 2 (2024)
- Pages: 349-355
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/257585
- DOI: https://doi.org/10.31857/S0006302924020174
- EDN: https://elibrary.ru/OTQFQM
- ID: 257585
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Abstract
It has been demonstrated that “Oxacom”, a freeze-dried preparation, retains, throughout its period of storage in the ampoule in the absence of oxygen for 15 years at ambient temperature, the same hypotensive activity due to the presence of a binuclear form of dinitrosyl iron complex with glutathione. It is suggested that an oxidation reaction where glutathione ligands as constituents of dinitrosyl iron complexes react with the oxygen, the content of which gradually increase in the preparation, could lead to the degradation of these complexes, but it was prevented due to the presence of a considerable amount of free, not included in dinitrosyl iron complexes glutathione molecules in this preparation.
Keywords
About the authors
A. F Vanin
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
Email: vanin.dnic@gmail.com
Moscow, Russia
A. A Abramov
E.I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian FederationMoscow, Russia
A. A Timoshin
E.I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian FederationMoscow, Russia
V. L Lakomkin
E.I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian FederationMoscow, Russia
N. A Tkachev
N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of SciencesMoscow, Russia
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