Email this article Mechanism of the cytotoxic effect of noble metal polyacrylates on tumor cells
- Authors: Chigasova A.K1, Ostrovskaya L.A1, Korman D.B1, Bluhterova N.V1
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 68, No 6 (2023)
- Pages: 1187-1199
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/249690
- DOI: https://doi.org/10.31857/S0006302923060108
- EDN: https://elibrary.ru/RORUYD
- ID: 249690
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Abstract
The present study was carried out to investigate and compare the cytotoxic activities and mechanism of action of gold polyacrylates (aurumacryl) and silver polyacrylates (argacryl) using human tumor cell line (MCF-7 cell culture). The tested compounds showed high cytotoxic activity. It was found that argacryl is 20 times more effective than aurumacryl. It was established that apoptosis represents the dominant mechanism by which tumor cells undergo cell death induced by aurumacryl and argacryl. Differences in the effect of drugs on the DNA structure in tumor cells were found.
About the authors
A. K Chigasova
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
L. A Ostrovskaya
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: larros@list.ru
Moscow, Russia
D. B Korman
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
N. V Bluhterova
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
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