Peculiarities of adaptational changes in leukocytes and platelets of yakutian ground squirrels during the pre-hibernation period in autumn

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Abstract

Earlier, it was shown that a series of physiological and biochemical changes in Yakutian long-tailed ground squirrels start to happen during autumn (the pre-hibernation period): in the brain, heart, skeletal muscles, etc. This study was conducted to analyze the composition of peripheral blood cells obtained from Yakutian ground squirrels in autumn, and for the first time an increase in the total number of leukocytes, particularly granulocytes, and a decrease in the number of lymphocytes were observed when compared with those obtained in summer; a shift of the leukogram from the lymphocytic fraction to the granulocytic fraction was revealed. Significant increase in a platelet count and thrombocrit with preservation of the percentage ratio of mature and young cell fractions was shown. Still, information on the cellular components of blood during the autumn season when hibernators prepare for winter months of hibernation remains scarce. Nonetheless, the results of our study indicate that there are very significant adaptive changes that occur in leukocytes and platelets of ground squirrels in this period. Possible causes of these changes are discussed.

About the authors

P. O Teplova

Institute of Cell Biophysics, Russian Academy of Sciences

Email: p.o.teplova@gmail.com
Pushchino, Moscow Region, Russia

N. P Komelina

Institute of Cell Biophysics, Russian Academy of Sciences

Pushchino, Moscow Region, Russia

K. I Lizorkina

Institute of Cell Biophysics, Russian Academy of Sciences

Pushchino, Moscow Region, Russia

N. M Zakharova

Institute of Cell Biophysics, Russian Academy of Sciences

Pushchino, Moscow Region, Russia

References

  1. H. R. Bouma, A. M. Strijkstra, A. S. Boerema, et al., Vet. Immunol. Immunopathol., 136, 319 (2010).
  2. N. K. Klichkhanov, E. R. Nikitina, Z. M. Shihamirova, et al., Front. Physiol., 12, 730657 (2021).
  3. S. Popova, A. Ulanova, Y. Gritsyna, et al., Sci. Reports, 10, 15185 (2020).
  4. Е. В. Карадулева, И. М. Санталова и Н. М. Захарова, Биофизика, 57, 926 (2014).
  5. М. В. Лазарева, К. О. Трапезникова, И. М. Вихлянцев и др., Биофизика, 57, 982 (2012).
  6. М. В. Онуфриев, Т. П. Семенова, Е. П. Волкова и др., Нейрохимия, 33, 103 (2016).
  7. Т. П. Семенова и Н. М. Захарова, Рос. физиол. журн. им. И.М. Сеченова, 99, 1265 (2002).
  8. Т. П. Семенова, Л. А. Спиридонова и Н. М. Захарова, Рос. физиол. журн. им. И.М. Сеченова, 100, 1068 (2014).
  9. А. И. Ануфриев и И. М. Охлопков, Экология, 2, 125 (2015)
  10. J. E. Szilagyi and J. B. Senturia, Cryobiology, 9, 257 (1972).
  11. H. R. Bouma, H. V. Carey, and F. G. M. Kroese, J. Leukoc. Biol., 88, 619 (2010).
  12. A. Hidalgo, E. R. Chilvers, C. Summers, et al., Trends Immunol., 40, 584 (2019).
  13. M. Franco, C. Contreras, and R. F Nespolo, Comp. Biochem. Physiol. A, 166, 338 (2013).
  14. Y. Yasuma, R. M. McCarron, M. Spatz, et al., Am. J. Physiol., 273, 1861 (1997).
  15. Г. В. Алексеева и В. М. Юнкер, Изв. СО АН СССР, 5 (1), 124 (1974).
  16. Г. В. Алексеева, В. М. Юнкер и О.П. Федорова, Известия СО АН СССР, 92 (1974).
  17. А. И. Ануфриев, Механизмы зимней спячки мелких млекопитающих Якутии (СО РАН, Новосибирск., 2008).
  18. P. Suomalainen and V. Rosokivi, Suomalainen Tiedeakatemia toimituksia. Sar. A.4: Biologica, 198, 1 (1973).
  19. E. L. d.Vrij, Thesis of Doctor of Philosophy (University of Groningen, Groningen, 2019).
  20. E. Parretta, G. Cassese, A. Santoni, et al., J. Immunol., 180, 7230 (2008).
  21. J. Sprent and D. F. Tough, Science (New York), 265, 1395 (1994).
  22. P. Inkovaara and P. Suomalainen, Ann. Acad. Sci. Fenn. Biol., 200, 1 (1973).
  23. C. C. Kurtz and H. V. Carey, Develop.Comp. Immunol., 31, 415 (2007).
  24. С. Г. Колаева, Е. Г. Новоселова, З. Г. Амерханов и др., Цитология, 45, 628 (2003).
  25. E. G. Novoselova, A. V. Kulikov, O. V. Glushkova, et al., Dokl. Biol. Sci., 397, 272 (2004).
  26. L. Kovalchuk, V. Mishchenko, and L. Chernaya, Zoology and Ecology, 27, 168 (2017).
  27. Л. И.Лешкович, Изв. Гос. противочумн. ин-та Сибири и Дальнего Востока, 8, 70 (1950).
  28. В. М. Юнкер, Г. В. Алексеева и Е. В. Фомина, Ж. эвол. биохим. и физиол., 10, 193 (1974).
  29. N. Abramson and B. Melton, Am. Fam. Physician, 62, 2053 (2000).
  30. E. L. dVrij, P. C. Vogelaar, M. Goris, et al., PloS One, 9, 603 (2014).
  31. E. L. dVrij, H. R. Bouma, M. Goris, et al., J.Comp. Physiol. B, 191, 603 (2021).
  32. S. Cooper, S. Lloyd, A. Koch, et al., J.Comp. Physiol. B, 187, 815 (2017).
  33. L. Corash, H. Y. Chen, J. Levin, et al., Blood, 70, 177 (1987).
  34. B. G. Yushkov, Bull. Sib. Med., 20, 216 (2021).

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