Email this article Induction of damage to the dna structure of tumor cells by aurum polyacrylate
- Authors: Chigasova A.K1, Ostrovskaya L.A1, Korman D.B1
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 68, No 1 (2023)
- Pages: 11-19
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/144400
- DOI: https://doi.org/10.31857/S0006302923010027
- EDN: https://elibrary.ru/NYQIWK
- ID: 144400
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Abstract
The ability of aurum polyacrylate (aurumacryl) to cause changes in the DNA structure of tumor cells (culture of MCF-7 human breast cancer cells) was studied. It was established that the molecular mechanism under- lying the effects of aurumacryl on tumor cells is associated with the induction of single-strand breaks and cross-links in the DNA molecule. At the same time, it was shown that aurumacryl can reduce the number of spontaneous, or irradiated, DNA double-strand breaks in MCF-7 cells.
About the authors
A. K Chigasova
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
L. A Ostrovskaya
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: larros@list.ru
Moscow, Russia
D. B Korman
Emanuel Institute of Biochemical Physics, Russian Academy of SciencesMoscow, Russia
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