The Effect of Experimental Hyperthyroidism on Characteristics of Actin–Myosin Interaction in Fast and Slow Skeletal Muscles
- 作者: Kopylova G.1, Shchepkin D.1, Bershitsky S.1
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隶属关系:
- Institute of Immunology and Physiology
- 期: 卷 83, 编号 5 (2018)
- 页面: 527-533
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151652
- DOI: https://doi.org/10.1134/S000629791805005X
- ID: 151652
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详细
The molecular mechanism of the failure of contractile function of skeletal muscles caused by oxidative damage to myosin in hyperthyroidism is not fully understood. Using an in vitro motility assay, we studied the effect of myosin damage caused by oxidative stress in experimental hyperthyroidism on the actin–myosin interaction and its regulation by calcium. We found that hyperthyroidism-induced oxidation of myosin is accompanied by a decrease in the sliding velocity of the regulated thin filaments in the in vitro motility assay, and this effect is increased with the duration of the pathological process.
作者简介
G. Kopylova
Institute of Immunology and Physiology
编辑信件的主要联系方式.
Email: g_rodionova@mail.ru
俄罗斯联邦, Yekaterinburg, 620049
D. Shchepkin
Institute of Immunology and Physiology
Email: g_rodionova@mail.ru
俄罗斯联邦, Yekaterinburg, 620049
S. Bershitsky
Institute of Immunology and Physiology
Email: g_rodionova@mail.ru
俄罗斯联邦, Yekaterinburg, 620049