Mitochondria-targeted antioxidant SkQ1 (10-(6′-plastoquinonyl)decyltriphenylphosphonium bromide) inhibits mast cell degranulation in vivo and in vitro
- 作者: Chelombitko M.1, Averina O.1, Vasilyeva T.1, Pletiushkina O.1, Popova E.1, Fedorov A.1, Chernyak B.1, Shishkina V.1, Ilinskaya O.1
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隶属关系:
- Lomonosov Moscow State University
- 期: 卷 82, 编号 12 (2017)
- 页面: 1493-1503
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151537
- DOI: https://doi.org/10.1134/S0006297917120082
- ID: 151537
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详细
The therapeutic effect of mitochondria-targeted antioxidant 10-(6′-plastoquinonyl)decyltriphenylphosphonium bromide (SkQ1) in experimental models of acute inflammation and wound repair has been shown earlier. It was suggested that the antiinflammatory activity of SkQ1 is related to its ability to suppress inflammatory activation of the vascular endothelium and neutrophil migration into tissues. Here, we demonstrated that SkQ1 inhibits activation of mast cells (MCs) followed by their degranulation and histamine release in vivo and in vitro. Intraperitoneal injections of SkQ1 in the mouse air-pouch model reduced the number of leukocytes in the air-pouch cavity and significantly decreased the histamine content in it, as well as suppressing MC degranulation in the air-pouch tissue. The direct effect of SkQ1 on MCs was studied in vitro in the rat basophilic leukemia RBL-2H3 cell line. SkQ1 inhibited induced degranulation of RBL-2H3 cells. These results suggest that mitochondrial reactive oxygen species are involved in the activation of MCs. It is known that MCs play a crucial role in regulation of vascular permeability by secreting histamine. Suppression of MC degranulation by SkQ1 might be a significant factor in the antiinflammatory activity of this mitochondria-targeted antioxidant.
作者简介
M. Chelombitko
Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
O. Averina
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119992
T. Vasilyeva
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
O. Pletiushkina
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
E. Popova
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
A. Fedorov
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
B. Chernyak
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
V. Shishkina
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991
O. Ilinskaya
Lomonosov Moscow State University
Email: atma69@yandex.ru
俄罗斯联邦, Moscow, 119991