The power and limitations of influenza virus hemagglutinin assays
- 作者: Ustinov N.1, Zavyalova E.1, Smirnova I.1, Kopylov A.1
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隶属关系:
- Lomonosov Moscow State University
- 期: 卷 82, 编号 11 (2017)
- 页面: 1234-1248
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151496
- DOI: https://doi.org/10.1134/S0006297917110025
- ID: 151496
如何引用文章
详细
Influenza virus hemagglutinins (HAs) are surface proteins that bind to sialic acid residues at the host cell surface and ensure further virus internalization. Development of methods for the inhibition of these processes drives progress in the design of new antiviral drugs. The state of the isolated HA (i.e. combining tertiary structure and extent of oligomerization) is defined by multiple factors, like the HA source and purification method, posttranslational modifications, pH, etc. The HA state affects HA functional activity and significantly impacts the results of numerous HA assays. In this review, we analyze the power and limitations of currently used HA assays regarding the state of HA.
作者简介
N. Ustinov
Lomonosov Moscow State University
Email: zlenka2006@gmail.com
俄罗斯联邦, Moscow, 119991
E. Zavyalova
Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: zlenka2006@gmail.com
俄罗斯联邦, Moscow, 119991
I. Smirnova
Lomonosov Moscow State University
Email: zlenka2006@gmail.com
俄罗斯联邦, Moscow, 119991
A. Kopylov
Lomonosov Moscow State University
Email: zlenka2006@gmail.com
俄罗斯联邦, Moscow, 119991
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