Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA repair
- 作者: Kosova A.1, Khodyreva S.1,2, Lavrik O.1,2
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隶属关系:
- Institute of Chemical Biology and Fundamental Medicine
- Novosibirsk State University
- 期: 卷 82, 编号 6 (2017)
- 页面: 643-654
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151394
- DOI: https://doi.org/10.1134/S0006297917060013
- ID: 151394
如何引用文章
详细
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is widely known as a glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are unrelated to glycolysis. Some of these functions presume interaction of GAPDH with DNA, but the mechanism of its translocation to the nucleus is not fully understood. When in the nucleus, GAPDH participates in the initiation of apoptosis and transcription of genes involved in antiapoptotic pathways and cell proliferation and plays a role in the regulation of telomere length. Several authors have shown that GAPDH displays the uracil-DNA glycosylase activity and interacts with some types of DNA damages, such as apurinic/apyrimidinic sites, nucleotide analogs, and covalent DNA adducts with alkylating agents. Moreover, GAPDH can interact with proteins participating in DNA repair, such as APE1, PARP1, HMGB1, and HMGB2. In this review, the functions of GAPDH associated with DNA repair are discussed in detail.
作者简介
A. Kosova
Institute of Chemical Biology and Fundamental Medicine
Email: lavrik@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
S. Khodyreva
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University
Email: lavrik@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
O. Lavrik
Institute of Chemical Biology and Fundamental Medicine; Novosibirsk State University
编辑信件的主要联系方式.
Email: lavrik@niboch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
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