Effects of short-term exposure to lithium on antiapoptotic Bcl-xL protein expression in cortex and hippocampus of rats after acute stress
- 作者: Dygalo N.1,2, Bannova A.1, Sukhareva E.1,2, Shishkina G.1, Ayriyants K.1,2, Kalinina T.1,2
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隶属关系:
- Institute of Cytology and Genetics
- Novosibirsk State University
- 期: 卷 82, 编号 3 (2017)
- 页面: 345-350
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151301
- DOI: https://doi.org/10.1134/S0006297917030130
- ID: 151301
如何引用文章
详细
The antiapoptotic protein Bcl-xL is involved in development of neurobiological resilience to stress; hence, the possibility of use of psychotropic drugs to increase its expression in brain in response to stress is of considerable interest. Lithium is a neurotropic drug widely used in psychiatry. In work, we studied effects of lithium administration (for 2 or 7 days) on the expression of Bcl-xL mRNA and protein in the hippocampi and cortices of rats subjected to stress that induced depression-like behavior in the animals. In contrast to the brain-derived neurotrophic factor (BDNF), whose expression decreased in the hippocampus in response to acute stress, stress increased the level of Bcl-xL mRNA in the hippocampus, but decreased it in the frontal cortex. Treatment of stressed animals with lithium for 2 or 7 days increased Bcl-xL protein levels 1.5-fold in the hippocampus, but it decreased them in the cortex. Therefore, Bcl-xL expression in the brain can be modulated by both stress and psychotropic drugs, and the effects of these factors are brain region-specific: both stress exposure and lithium administration activated Bcl-xL expression in the hippocampus and suppressed it in the frontal cortex. The activation of Bcl-xL expression in the hippocampus by lithium, demonstrated for the first time in this study, suggests an important role of this protein in the therapeutic effects of lithium in the treatment of stress-induced psychoemotional disorders.
作者简介
N. Dygalo
Institute of Cytology and Genetics; Novosibirsk State University
编辑信件的主要联系方式.
Email: dygalo@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
A. Bannova
Institute of Cytology and Genetics
Email: dygalo@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
E. Sukhareva
Institute of Cytology and Genetics; Novosibirsk State University
Email: dygalo@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
G. Shishkina
Institute of Cytology and Genetics
Email: dygalo@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090
K. Ayriyants
Institute of Cytology and Genetics; Novosibirsk State University
Email: dygalo@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
T. Kalinina
Institute of Cytology and Genetics; Novosibirsk State University
Email: dygalo@bionet.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090