Interplay between brain BDNF and glutamatergic systems: A brief state of the evidence and association with the pathogenesis of depression
- 作者: Gulyaeva N.1
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隶属关系:
- Institute of Higher Nervous Activity and Neurophysiology
- 期: 卷 82, 编号 3 (2017)
- 页面: 301-307
- 栏目: Mini-Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151288
- DOI: https://doi.org/10.1134/S0006297917030087
- ID: 151288
如何引用文章
详细
The excitatory neurotransmitter glutamate system and the brain-derived neurotrophic factor (BDNF) system are principally involved in phenomena of cellular and synaptic plasticity. These systems are interacting, and disclosing mechanisms of such interactions is critically important for understanding the machinery of neuroplasticity and its modulation in normal and pathological situations. The short state of evidence in this review addresses experimentally confirmed connections of these mechanisms and their potential relation to the pathogenesis of depression. The connections between the two systems are numerous and bidirectional, providing for mutual regulation of the glutamatergic and BDNF systems. The available data suggest that it is complex and well-coordinating nature of these connections that secures optimal synaptic and cellular plasticity in the normal brain. Both systems are associated with the pathogenesis of depression, and the disturbance of tight and well-balanced associations between them results in unfavorable changes in neuronal plasticity underlying depressive disorders and other mood diseases.
作者简介
N. Gulyaeva
Institute of Higher Nervous Activity and Neurophysiology
编辑信件的主要联系方式.
Email: nata_gul@mail.ru
俄罗斯联邦, Moscow, 117485
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