Investigation of ribosomes using molecular dynamics simulation methods
- 作者: Makarov G.1,2, Makarova T.1,2, Sumbatyan N.1,2, Bogdanov A.1,2
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隶属关系:
- Belozersky Institute of Physico-Chemical Biology
- Lomonosov Moscow State University, Chemistry Department
- 期: 卷 81, 编号 13 (2016)
- 页面: 1579-1588
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151173
- DOI: https://doi.org/10.1134/S0006297916130010
- ID: 151173
如何引用文章
详细
The ribosome as a complex molecular machine undergoes significant conformational changes while synthesizing a protein molecule. Molecular dynamics simulations have been used as complementary approaches to X-ray crystallography and cryoelectron microscopy, as well as biochemical methods, to answer many questions that modern structural methods leave unsolved. In this review, we demonstrate that all-atom modeling of ribosome molecular dynamics is particularly useful in describing the process of tRNA translocation, atomic details of behavior of nascent peptides, antibiotics, and other small molecules in the ribosomal tunnel, and the putative mechanism of allosteric signal transmission to functional sites of the ribosome.
作者简介
G. Makarov
Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Chemistry Department
Email: bogdanov@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991
T. Makarova
Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Chemistry Department
Email: bogdanov@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991
N. Sumbatyan
Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Chemistry Department
Email: bogdanov@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991
A. Bogdanov
Belozersky Institute of Physico-Chemical Biology; Lomonosov Moscow State University, Chemistry Department
编辑信件的主要联系方式.
Email: bogdanov@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991