Role of nuclear constitutive androstane receptor in regulation of hepatocyte proliferation and hepatocarcinogenesis
- 作者: Kazantseva Y.1, Pustylnyak Y.1,2, Pustylnyak V.1,2
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隶属关系:
- Institute of Molecular Biology and Biophysics
- Novosibirsk State University
- 期: 卷 81, 编号 4 (2016)
- 页面: 338-347
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150826
- DOI: https://doi.org/10.1134/S0006297916040040
- ID: 150826
如何引用文章
详细
Activation of the constitutive androstane receptor (CAR) in hepatocytes occurs as a body adaptation in response to a number of external influences, and its functional activity is primarily related to induction of enzymes detoxifying xenobiotics. However, special attention was recently given to CAR due to the fact that its key role becomes unveiled in various physiological and pathophysiological processes occurring in the liver: gluconeogenesis, metabolism of fatty acids and bilirubin, hormonal regulation, proliferation of hepatocytes, and hepatocarcinogenesis. Here we review the main pathways and mechanisms that elevate hepatocyte proliferative activity related to CAR and whose disturbance may be a pivotal factor in hepatocarcinogenesis.
作者简介
Y. Kazantseva
Institute of Molecular Biology and Biophysics
Email: pustylnyak@ngs.ru
俄罗斯联邦, Novosibirsk, 630117
Y. Pustylnyak
Institute of Molecular Biology and Biophysics; Novosibirsk State University
Email: pustylnyak@ngs.ru
俄罗斯联邦, Novosibirsk, 630117; Novosibirsk, 630090
V. Pustylnyak
Institute of Molecular Biology and Biophysics; Novosibirsk State University
编辑信件的主要联系方式.
Email: pustylnyak@ngs.ru
俄罗斯联邦, Novosibirsk, 630117; Novosibirsk, 630090