Study of age-dependent structural and functional changes of mitochondria in skeletal muscles and heart of naked mole rats (Heterocephalus glaber)
- Авторы: Holtze S.1, Eldarov C.2, Vays V.2, Vangeli I.2, Vysokikh M.2, Bakeeva L.2, Skulachev V.2, Hildebrandt T.1
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Учреждения:
- Leibniz Institute for Zoo and Wildlife Research, Department of Reproduction Management
- Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
- Выпуск: Том 81, № 12 (2016)
- Страницы: 1429-1437
- Раздел: Phenoptosis (Special Issue)
- URL: https://journals.rcsi.science/0006-2979/article/view/151129
- DOI: https://doi.org/10.1134/S000629791612004X
- ID: 151129
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Аннотация
Morphometric analysis of mitochondria in skeletal muscles and heart of 6- and 60-month-old naked mole rats (Heterocephalus glaber) revealed a significant age-dependent increase in the total area of mitochondrial cross-sections in studied muscle fibers. For 6- and 60-month-old animals, these values were 4.8 ± 0.4 and 12.7 ± 1.8%, respectively. This effect is mainly based on an increase in the number of mitochondria. In 6-month-old naked mole rats, there were 0.23 ± 0.02 mitochondrial cross-sections per μm2 of muscle fiber, while in 60-month-old animals this value was 0.47 ± 0.03. The average area of a single mitochondrial cross-section also increased with age in skeletal muscles–from 0.21 ± 0.01 to 0.29 ± 0.03 μm2. Thus, naked mole rats show a drastic enlargement of the mitochondrial apparatus in skeletal muscles with age due to an increase in the number of mitochondria and their size. They possess a neotenic type of chondriome accompanied by specific features of mitochondrial functioning in the state of oxidative phosphorylation and a significant decrease in the level of matrix adenine nucleotides.
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Об авторах
S. Holtze
Leibniz Institute for Zoo and Wildlife Research, Department of Reproduction Management
Автор, ответственный за переписку.
Email: holtze@izw-berlin.de
Германия, Berlin, 10315
C. Eldarov
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: bakeeva@belozersky.msu.ru
Россия, Moscow, 119991
V. Vays
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: bakeeva@belozersky.msu.ru
Россия, Moscow, 119991
I. Vangeli
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: bakeeva@belozersky.msu.ru
Россия, Moscow, 119991
M. Vysokikh
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Автор, ответственный за переписку.
Email: mike@genebee.msu.ru
Россия, Moscow, 119991
L. Bakeeva
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Автор, ответственный за переписку.
Email: bakeeva@belozersky.msu.ru
Россия, Moscow, 119991
V. Skulachev
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology
Email: bakeeva@belozersky.msu.ru
Россия, Moscow, 119991
T. Hildebrandt
Leibniz Institute for Zoo and Wildlife Research, Department of Reproduction Management
Email: bakeeva@belozersky.msu.ru
Германия, Berlin, 10315