Possible interventions to modify aging
- Авторы: Libertini G.1, Ferrara N.1
-
Учреждения:
- Federico II University, Department of Translational Medical Sciences
- Выпуск: Том 81, № 12 (2016)
- Страницы: 1413-1428
- Раздел: Phenoptosis (Special Issue)
- URL: https://journals.rcsi.science/0006-2979/article/view/151127
- DOI: https://doi.org/10.1134/S0006297916120038
- ID: 151127
Цитировать
Аннотация
The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level. This function is implemented, according to the telomere theory, through mechanisms that operate through the subtelomere–telomere–telomerase system. After reviewing some necessary technical and ethical reservations and providing a concise description of aging mechanisms, this work considers interventions that could lead to the control of some highly disabling characteristics of aging, such as Alzheimer’s and Parkinson’s syndromes and age-related macular degeneration, and afterwards to a full control of aging up to a condition equivalent to that of the species defined as “with negligible senescence”. The various steps needed for the development of such interventions are described along general lines.
Ключевые слова
Об авторах
Giacinto Libertini
Federico II University, Department of Translational Medical Sciences
Автор, ответственный за переписку.
Email: giacinto.libertini@tin.it
Италия, Naples, 80138
Nicola Ferrara
Federico II University, Department of Translational Medical Sciences
Email: giacinto.libertini@tin.it
Италия, Naples, 80138