Possible interventions to modify aging
- Autores: Libertini G.1, Ferrara N.1
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Afiliações:
- Federico II University, Department of Translational Medical Sciences
- Edição: Volume 81, Nº 12 (2016)
- Páginas: 1413-1428
- Seção: Phenoptosis (Special Issue)
- URL: https://journals.rcsi.science/0006-2979/article/view/151127
- DOI: https://doi.org/10.1134/S0006297916120038
- ID: 151127
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Resumo
The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level. This function is implemented, according to the telomere theory, through mechanisms that operate through the subtelomere–telomere–telomerase system. After reviewing some necessary technical and ethical reservations and providing a concise description of aging mechanisms, this work considers interventions that could lead to the control of some highly disabling characteristics of aging, such as Alzheimer’s and Parkinson’s syndromes and age-related macular degeneration, and afterwards to a full control of aging up to a condition equivalent to that of the species defined as “with negligible senescence”. The various steps needed for the development of such interventions are described along general lines.
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Sobre autores
Giacinto Libertini
Federico II University, Department of Translational Medical Sciences
Autor responsável pela correspondência
Email: giacinto.libertini@tin.it
Itália, Naples, 80138
Nicola Ferrara
Federico II University, Department of Translational Medical Sciences
Email: giacinto.libertini@tin.it
Itália, Naples, 80138