Отправить статью по E-mail Effects of fibroin microcarriers on inflammation and regeneration of deep skin wounds in mice
- Авторы: Arkhipova A.1, Nosenko M.1,2, Malyuchenko N.1, Zvartsev R.2, Moisenovich A.2, Zhdanova A.1,2, Vasil’eva T.1, Gorshkova E.1,2, Agapov I.3, Drutskaya M.1,2, Nedospasov S.1,2,4, Moisenovich M.1
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Учреждения:
- Biological Faculty
- Engelhardt Institute of Molecular Biology
- Shumakov Research Institute of Transplantation and Artificial Organs
- Belozersky Institute of Physico-Chemical Biology
- Выпуск: Том 81, № 11 (2016)
- Страницы: 1251-1260
- Раздел: Molecular and Cellular Mechanisms of Inflammation (Special Issue) Guest Editors S. A. Nedospasov and D. V. Kuprash
- URL: https://journals.rcsi.science/0006-2979/article/view/151076
- DOI: https://doi.org/10.1134/S0006297916110031
- ID: 151076
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Аннотация
The process of tissue regeneration following damage takes place with direct participation of the immune system. The use of biomaterials as scaffolds to facilitate healing of skin wounds is a new and interesting area of regenerative medicine and biomedical research. In many ways, the regenerative potential of biological material is related to its ability to modulate the inflammatory response. At the same time, all foreign materials, once implanted into a living tissue, to varying degree cause an immune reaction. The modern approach to the development of bioengineered structures for applications in regenerative medicine should be directed toward using the properties of the inflammatory response that improve healing, but do not lead to negative chronic manifestations. In this work, we studied the effect of microcarriers comprised of either fibroin or fibroin supplemented with gelatin on the dynamics of the healing, as well as inflammation, during regeneration of deep skin wounds in mice. We found that subcutaneous administration of microcarriers to the wound area resulted in uniform contraction of the wounds in mice in our experimental model, and microcarrier particles induced the infiltration of immune cells. This was associated with increased expression of proinflammatory cytokines TNF, IL-6, IL-1β, and chemokines CXCL1 and CXCL2, which contributed to full functional recovery of the injured area and the absence of fibrosis as compared to the control group.
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Об авторах
A. Arkhipova
Biological Faculty
Email: marinadru@gmail.com
Россия, Moscow, 119991
M. Nosenko
Biological Faculty; Engelhardt Institute of Molecular Biology
Email: marinadru@gmail.com
Россия, Moscow, 119991; Moscow, 119991
N. Malyuchenko
Biological Faculty
Email: marinadru@gmail.com
Россия, Moscow, 119991
R. Zvartsev
Engelhardt Institute of Molecular Biology
Email: marinadru@gmail.com
Россия, Moscow, 119991
A. Moisenovich
Engelhardt Institute of Molecular Biology
Email: marinadru@gmail.com
Россия, Moscow, 119991
A. Zhdanova
Biological Faculty; Engelhardt Institute of Molecular Biology
Email: marinadru@gmail.com
Россия, Moscow, 119991; Moscow, 119991
T. Vasil’eva
Biological Faculty
Email: marinadru@gmail.com
Россия, Moscow, 119991
E. Gorshkova
Biological Faculty; Engelhardt Institute of Molecular Biology
Email: marinadru@gmail.com
Россия, Moscow, 119991; Moscow, 119991
I. Agapov
Shumakov Research Institute of Transplantation and Artificial Organs
Email: marinadru@gmail.com
Россия, Moscow, 113182
M. Drutskaya
Biological Faculty; Engelhardt Institute of Molecular Biology
Автор, ответственный за переписку.
Email: marinadru@gmail.com
Россия, Moscow, 119991; Moscow, 119991
S. Nedospasov
Biological Faculty; Engelhardt Institute of Molecular Biology; Belozersky Institute of Physico-Chemical Biology
Email: marinadru@gmail.com
Россия, Moscow, 119991; Moscow, 119991; Moscow, 119991
M. Moisenovich
Biological Faculty
Email: marinadru@gmail.com
Россия, Moscow, 119991
