Cytokines as Mediators of Neuroinflammation in Experimental Autoimmune Encephalomyelitis
- Autores: Gogoleva V.1,2, Atretkhany K.1,2, Drutskaya M.1,2, Mufazalov I.3, Kruglov A.4, Nedospasov S.1,2,4
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Afiliações:
- Engelhardt Institute of Molecular Biology
- Biological Faculty
- University of California
- Belozersky Institute of Physico-Chemical Biology
- Edição: Volume 83, Nº 9 (2018)
- Páginas: 1089-1103
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151719
- DOI: https://doi.org/10.1134/S0006297918090110
- ID: 151719
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Resumo
Cytokines play a pivotal role in maintaining homeostasis of the immune system and in regulation of the immune response. Cytokine dysregulation is often associated with development of various pathological conditions, including autoimmunity. Recent studies have provided insights into the cytokine signaling pathways that are involved not only in pathogenesis of autoimmune neuroinflammatory disorders, such as multiple sclerosis, but also in neurodegenerative states, for example, Alzheimer’s disease. Understanding the exact molecular mechanisms of disease pathogenesis and evaluation of relevant experimental animal models are necessary for development of effective therapeutic approaches.
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Sobre autores
V. Gogoleva
Engelhardt Institute of Molecular Biology; Biological Faculty
Autor responsável pela correspondência
Email: violettegogoleva@mail.ru
Rússia, Moscow, 119991; Moscow, 119234
K. Atretkhany
Engelhardt Institute of Molecular Biology; Biological Faculty
Email: sergei.nedospasov@gmail.com
Rússia, Moscow, 119991; Moscow, 119234
M. Drutskaya
Engelhardt Institute of Molecular Biology; Biological Faculty
Email: sergei.nedospasov@gmail.com
Rússia, Moscow, 119991; Moscow, 119234
I. Mufazalov
University of California
Email: sergei.nedospasov@gmail.com
Estados Unidos da América, San Francisco, CA, 94143
A. Kruglov
Belozersky Institute of Physico-Chemical Biology
Email: sergei.nedospasov@gmail.com
Rússia, Moscow, 119234
S. Nedospasov
Engelhardt Institute of Molecular Biology; Biological Faculty; Belozersky Institute of Physico-Chemical Biology
Autor responsável pela correspondência
Email: sergei.nedospasov@gmail.com
Rússia, Moscow, 119991; Moscow, 119234; Moscow, 119234
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