Exogenous 8-oxo-7,8-dihydro-2′-deoxyguanosine: Biomedical properties, mechanisms of action, and therapeutic potential
- Autores: Chernikov A.1, Gudkov S.2,3,4, Usacheva A.1, Bruskov V.1,5
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Afiliações:
- Institute of Theoretical and Experimental Biophysics
- Moscow Regional Research and Clinical Institute (MONIKI)
- Prokhorov Institute of General Physics
- Lobachevsky State University of Nizhnii Novgorod
- Pushchino State Research Institute for Natural Sciences
- Edição: Volume 82, Nº 13 (2017)
- Páginas: 1686-1701
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151556
- DOI: https://doi.org/10.1134/S0006297917130089
- ID: 151556
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Resumo
Abstract—8-Oxo-7,8-dihydroguanine (8-oxo-G) is a key biomarker of oxidative damage to DNA in cells, and its genotox- icity is well-studied. In recent years, it has been confirmed experimentally that free 8-oxo-G and molecules containing it are not merely inert products of DNA repair or degradation, but they are actively involved in intracellular signaling. In this review, data are systematized indicating that free 8-oxo-G and oxidized (containing 8-oxo-G) extracellular DNA function in the body as mediators of stress signaling and initiate inflammatory and immune responses to maintain homeostasis under the action of external pathogens, whereas exogenous 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGuo) exhibits pro- nounced antiinflammatory and antioxidant properties. This review describes known action mechanisms of oxidized guanine and 8-oxo-G-containing molecules. Prospects for their use as a therapeutic target are considered, as well as a pharmaceu- tical agent for treatment of a wide range of diseases whose pathogenesis is significantly contributed to by inflammation and oxidative stress.
Sobre autores
A. Chernikov
Institute of Theoretical and Experimental Biophysics
Email: bruskov_vi@rambler.ru
Rússia, Pushchino, Moscow Region, 142292
S. Gudkov
Moscow Regional Research and Clinical Institute (MONIKI); Prokhorov Institute of General Physics; Lobachevsky State University of Nizhnii Novgorod
Email: bruskov_vi@rambler.ru
Rússia, Moscow, 129110; Moscow, 119991; Nizhnii Novgorod, 603950
A. Usacheva
Institute of Theoretical and Experimental Biophysics
Email: bruskov_vi@rambler.ru
Rússia, Pushchino, Moscow Region, 142292
V. Bruskov
Institute of Theoretical and Experimental Biophysics; Pushchino State Research Institute for Natural Sciences
Autor responsável pela correspondência
Email: bruskov_vi@rambler.ru
Rússia, Pushchino, Moscow Region, 142292; Moscow Region, 142290 Pushchino