Plant phenols and autophagy
- Autores: Zenkov N.1, Chechushkov A.1, Kozhin P.1, Kandalintseva N.2, Martinovich G.3, Menshchikova E.1
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Afiliações:
- Research Institute of Experimental and Clinical Medicine
- Novosibirsk State Pedagogical University
- Belarusian State University
- Edição: Volume 81, Nº 4 (2016)
- Páginas: 297-314
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/150818
- DOI: https://doi.org/10.1134/S0006297916040015
- ID: 150818
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Resumo
Many plant phenols (stilbenes, curcumins, catechins, flavonoids, etc.) are effective antioxidants and protect cells during oxidative stress. Extensive clinical studies on the potential of phenolic compounds for treatment of cardiovascular, neurodegenerative, oncological, and inflammatory diseases are now being conducted. In addition to direct antioxidant effect, plant phenols may provide a protective effect via activation of the Keap1/Nrf2/ARE redox-sensitive signaling system and regulation of autophagy. In this review, mechanisms of effects of the most common plant phenols on autophagy are presented.
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Sobre autores
N. Zenkov
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
Rússia, Novosibirsk, 630117
A. Chechushkov
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
Rússia, Novosibirsk, 630117
P. Kozhin
Research Institute of Experimental and Clinical Medicine
Email: lemen@centercem.ru
Rússia, Novosibirsk, 630117
N. Kandalintseva
Novosibirsk State Pedagogical University
Email: lemen@centercem.ru
Rússia, Novosibirsk, 630126
G. Martinovich
Belarusian State University
Email: lemen@centercem.ru
Belarus, Minsk, 220030
E. Menshchikova
Research Institute of Experimental and Clinical Medicine
Autor responsável pela correspondência
Email: lemen@centercem.ru
Rússia, Novosibirsk, 630117