Interaction between Saccharomyces cerevisiae mitochondrial DNA-binding protein Abf2p and Cce1p resolvase
- Авторлар: Samoilova E.1, Krasheninnikov I.1, Levitskii S.1
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Мекемелер:
- Faculty of Biology
- Шығарылым: Том 81, № 10 (2016)
- Беттер: 1111-1117
- Бөлім: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151036
- DOI: https://doi.org/10.1134/S0006297916100096
- ID: 151036
Дәйексөз келтіру
Аннотация
Mitochondrial DNA is susceptible to the action of reactive oxygen species generated by the reactions of oxidative phosphorylation. Homologous recombination is one of the mechanisms providing integrity of the mitochondrial genome. Some proteins that take part in this process in budding yeast mitochondria have been identified. These include Abf2p, the major protein of the mt-nucleoid that specifically binds cruciform DNA, and Cce1p – Holliday junction resolvase. Here we show that Abf2p does not significantly affect either binding of Cce1p to branched DNA or rate and specificity of Holliday junction resolution. These data suggest the existence of an alternative homologous recombination pathway in yeast mitochondria.
Негізгі сөздер
Авторлар туралы
E. Samoilova
Faculty of Biology
Email: krolick@yandex.ru
Ресей, 119991, Moscow
I. Krasheninnikov
Faculty of Biology
Email: krolick@yandex.ru
Ресей, 119991, Moscow
S. Levitskii
Faculty of Biology
Хат алмасуға жауапты Автор.
Email: krolick@yandex.ru
Ресей, 119991, Moscow
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