Priming of human neutrophils is necessary for their activation by extracellular DNA
- Авторлар: Prikhodko A.1, Vitushkina M.2, Zinovkina L.1, Popova E.3, Zinovkin R.2,3
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Мекемелер:
- Faculty of Bioengineering and Bioinformatics
- Faculty of Biology
- Belozersky Institute of Physico-Chemical Biology
- Шығарылым: Том 81, № 6 (2016)
- Беттер: 609-614
- Бөлім: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/150911
- DOI: https://doi.org/10.1134/S0006297916060079
- ID: 150911
Дәйексөз келтіру
Аннотация
Extracellular plasma DNA is thought to act as a damage-associated molecular pattern causing activation of immune cells. However, purified preparations of mitochondrial and nuclear DNA were unable to induce neutrophil activation in vitro. Thus, we examined whether granulocyte-macrophage colony-stimulating factor (GM-CSF) acting as a neutrophil priming agent can promote the activation of neutrophils by different types of extracellular DNA. GM-CSF pretreatment greatly increased p38 MAPK phosphorylation and promoted CD11b/CD66b expression in human neutrophils treated with mitochondrial and, to a lesser extent, with nuclear DNA. Our experiments clearly indicate that GM-CSFinduced priming of human neutrophils is necessary for their subsequent activation by extracellular DNA.
Негізгі сөздер
Авторлар туралы
A. Prikhodko
Faculty of Bioengineering and Bioinformatics
Email: roman.zinovkin@gmail.com
Ресей, Moscow, 119991
M. Vitushkina
Faculty of Biology
Email: roman.zinovkin@gmail.com
Ресей, Moscow, 119991
L. Zinovkina
Faculty of Bioengineering and Bioinformatics
Email: roman.zinovkin@gmail.com
Ресей, Moscow, 119991
E. Popova
Belozersky Institute of Physico-Chemical Biology
Email: roman.zinovkin@gmail.com
Ресей, Moscow, 119991
R. Zinovkin
Faculty of Biology; Belozersky Institute of Physico-Chemical Biology
Хат алмасуға жауапты Автор.
Email: roman.zinovkin@gmail.com
Ресей, Moscow, 119991; Moscow, 119991