Cerebral mechanisms of hypoxic/ischemic postconditioning
- Authors: Vetrovoy O.V.1,2, Rybnikova E.A.1, Samoilov M.O.1
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Affiliations:
- Pavlov Institute of Physiology
- St. Petersburg State University
- Issue: Vol 82, No 3 (2017)
- Pages: 392-400
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151318
- DOI: https://doi.org/10.1134/S000629791703018X
- ID: 151318
Cite item
Abstract
This review analyzes recent data on mechanisms of cerebral hypoxia and the protective methods of hypoxic and ischemic postconditioning, as well as their interrelationship with the key mechanisms responsible for neuroprotection and neuroplasticity. Upregulation of expression of antiapoptotic factors and neurotrophins and modulation of activity of several protein kinases and transcription factors such as hypoxia-inducible factor-1 (HIF-1) are considered as the most important aspects in the neuroprotective potential of postconditioning. The presented information indicates substantial transformative promise of the noninvasive techniques of hypoxic postconditioning as well as significant similarity between the adaptive pathways activated by various postconditioning methods, which are far from being fully understood.
About the authors
O. V. Vetrovoy
Pavlov Institute of Physiology; St. Petersburg State University
Author for correspondence.
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
E. A. Rybnikova
Pavlov Institute of Physiology
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg, 199034
M. O. Samoilov
Pavlov Institute of Physiology
Email: vov210292@yandex.ru
Russian Federation, St. Petersburg, 199034
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