Email this article Molecular mechanisms mediating involvement of glial cells in brain plastic remodeling in epilepsy
- Authors: Khaspekov L.G.1, Frumkina L.E.1
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Affiliations:
- Department of Brain Research
- Issue: Vol 82, No 3 (2017)
- Pages: 380-391
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151313
- DOI: https://doi.org/10.1134/S0006297917030178
- ID: 151313
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Abstract
In this review we summarize published data on the involvement of glial cells in molecular mechanisms underlying brain plastic reorganization in epilepsy. The role of astrocytes as glial elements in pathological plasticity in epilepsy is discussed. Data on the involvement of aquaporin-4 in epileptogenic plastic changes and on participation of microglia and extracellular matrix in dysregulation of synaptic transmission and plastic remodeling in epileptic brain tissue are reviewed.
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About the authors
L. G. Khaspekov
Department of Brain Research
Author for correspondence.
Email: khaspekleon@mail.ru
Russian Federation, Moscow, 105064
L. E. Frumkina
Department of Brain Research
Email: khaspekleon@mail.ru
Russian Federation, Moscow, 105064
