A new program for detecting the geometrical core of a set of structures of macromolecular complexes
- Authors: Vakulenko Y.A.1, Nagaev B.E.1, Alexeevski A.V.1,2,3, Karyagina A.S.2,4,5, Spirin S.A.1,2,3
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Affiliations:
- Faculty of Bioengineering and Bioinformatics
- Belozersky Institute of Physico-Chemical Biology
- Institute of System Studies
- Gamaleya Center of Epidemiology and Microbiology
- Institute of Agricultural Biotechnology
- Issue: Vol 81, No 4 (2016)
- Pages: 428-431
- Section: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/150854
- DOI: https://doi.org/10.1134/S0006297916040143
- ID: 150854
Cite item
Abstract
Comparison of structures of homological proteins often helps to understand functionally significant features of these structures. This concerns not only structures of separate protein chains, but also structures of macromolecular complexes. In particular, a comparison of complexes of homologous proteins with DNA is significant for analysis of the recognition of DNA by proteins. We present program LCore for detecting geometrical cores of a family of structures; a geometrical core is a set of amino acid residues and nucleotides that disposed similarly in all structures of the family. We describe the algorithm of the program, its web interface, and an example of its application to analysis of complexes of homeodomains with DNA.
About the authors
Yu. A. Vakulenko
Faculty of Bioengineering and Bioinformatics
Email: info@pleiadesonline.com
Russian Federation, Moscow, 119991
B. E. Nagaev
Faculty of Bioengineering and Bioinformatics
Email: info@pleiadesonline.com
Russian Federation, Moscow, 119991
A. V. Alexeevski
Faculty of Bioengineering and Bioinformatics; Belozersky Institute of Physico-Chemical Biology; Institute of System Studies
Email: info@pleiadesonline.com
Russian Federation, Moscow, 119991; Moscow, 119991; Moscow, 117218
A. S. Karyagina
Belozersky Institute of Physico-Chemical Biology; Gamaleya Center of Epidemiology and Microbiology; Institute of Agricultural Biotechnology
Email: info@pleiadesonline.com
Russian Federation, Moscow, 119991; Moscow, 123098; Moscow, 127550
S. A. Spirin
Faculty of Bioengineering and Bioinformatics; Belozersky Institute of Physico-Chemical Biology; Institute of System Studies
Author for correspondence.
Email: info@pleiadesonline.com
Russian Federation, Moscow, 119991; Moscow, 119991; Moscow, 117218