Prions and Non-infectious Amyloids of Mammals – Similarities and Differences
- Authors: Galkin A.P.1,2, Velizhanina M.E.2, Sopova Y.V.1,2, Shenfeld A.A.1,2, Zadorsky S.P.1,2
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Affiliations:
- St. Petersburg Branch of Vavilov Institute of General Genetics
- Department of Genetics and Biotechnology
- Issue: Vol 83, No 10 (2018)
- Pages: 1184-1195
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151734
- DOI: https://doi.org/10.1134/S0006297918100048
- ID: 151734
Cite item
Abstract
Amyloids are highly ordered aggregates of protein fibrils exhibiting cross-β structure formed by intermolecular hydrogen bonds. Pathological amyloid deposition is associated with the development of several socially significant incurable human diseases. Of particular interest are infectious amyloids, or prions, that cause several lethal neurodegenerative diseases in humans and can be transmitted from one organism to another. Because of almost complete absence of criteria for infectious and non-infectious amyloids, there is a lack of consensus, especially, in the definition of similarities and differences between prions and non-infectious amyloids. In this review, we formulated contemporary molecular-biological criteria for identification of prions and non-infectious amyloids and focused on explaining the differences between these two types of molecules.
Keywords
About the authors
A. P. Galkin
St. Petersburg Branch of Vavilov Institute of General Genetics; Department of Genetics and Biotechnology
Author for correspondence.
Email: apgalkin@mail.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
M. E. Velizhanina
Department of Genetics and Biotechnology
Email: apgalkin@mail.ru
Russian Federation, St. Petersburg, 199034
Yu. V. Sopova
St. Petersburg Branch of Vavilov Institute of General Genetics; Department of Genetics and Biotechnology
Email: apgalkin@mail.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
A. A. Shenfeld
St. Petersburg Branch of Vavilov Institute of General Genetics; Department of Genetics and Biotechnology
Email: apgalkin@mail.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
S. P. Zadorsky
St. Petersburg Branch of Vavilov Institute of General Genetics; Department of Genetics and Biotechnology
Email: apgalkin@mail.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
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