Recent Advances in the Studies of Molecular Mechanisms Regulating Multidrug Resistance in Cancer Cells
- Authors: Stavrovskaya A.A.1, Rybalkina E.Y.1
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Affiliations:
- Blokhin Medical Research Center of Oncology
- Issue: Vol 83, No 7 (2018)
- Pages: 779-786
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151682
- DOI: https://doi.org/10.1134/S0006297918070015
- ID: 151682
Cite item
Abstract
Abstract—Here we present new approaches to better understanding multidrug resistance (MDR) development in cancer cells, such as identification of components of a complex process of MDR evolution. Recent advances in the studies of MDR are discussed: 1) chemotherapy agents might be involved in the selection of cancer stem cells resulting in the elevated drug resistance and enhanced tumorigenicity; 2) cell–cell interactions have a great effect on the MDR emergence and evolution; 3) mechanotransduction is an important signaling mechanism in cell–cell interactions; 4) proteins of the ABC transporter family which are often involved in MDR might be transferred between cells via microvesicles (epigenetic MDR regulation); 5) proteins providing cell-to-cell transfer of functional P-glycoprotein (MDR1 protein) via microvesicles have been investigated; 6) P-glycoprotein may serve to regulate apoptosis, as well as transcription and translation of target genes/proteins. Although proving once again that MDR is a complex multi-faceted process, these data open new approaches to overcoming it.
About the authors
A. A. Stavrovskaya
Blokhin Medical Research Center of Oncology
Author for correspondence.
Email: astavrovskaya@yahoo.com
Russian Federation, Moscow, 115478
E. Yu. Rybalkina
Blokhin Medical Research Center of Oncology
Email: astavrovskaya@yahoo.com
Russian Federation, Moscow, 115478
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