Import of Proteins and Nucleic Acids into Mitochondria
- Authors: Verechshagina N.A.1, Konstantinov Y.M.2,3, Kamenski P.A.1,4, Mazunin I.O.1
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Affiliations:
- Institute of Living Systems
- Siberian Institute of Plant Physiology and Biochemistry
- Irkutsk State University
- Lomonosov Moscow State University, Faculty of Biology
- Issue: Vol 83, No 6 (2018)
- Pages: 643-661
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151667
- DOI: https://doi.org/10.1134/S0006297918060032
- ID: 151667
Cite item
Abstract
Many mitochondrial genes have been transferred to the nucleus in course of evolution. The products of expression of these genes, being still necessary for organelle function, are imported there from the cytosol. Molecular mechanisms of protein import are studied much deeper than those of nucleic acids. The latter, it seems to us, retards the development of mitochondrial genome editing technologies. In this review, we describe mechanisms of DNA, RNA, and protein import into mitochondria of different eukaryotes. The description is given for the natural processes, as well as for artificial targeting of macromolecules into mitochondria for therapy. Also, we discuss different approaches to introduce changes into the mitochondrial DNA sequence.
Keywords
About the authors
N. A. Verechshagina
Institute of Living Systems
Email: yukon@sifibr.irk.ru
Russian Federation, Kaliningrad, 236038
Yu. M. Konstantinov
Siberian Institute of Plant Physiology and Biochemistry; Irkutsk State University
Author for correspondence.
Email: yukon@sifibr.irk.ru
Russian Federation, Irkutsk, 664033; Irkutsk, 664003
P. A. Kamenski
Institute of Living Systems; Lomonosov Moscow State University, Faculty of Biology
Email: yukon@sifibr.irk.ru
Russian Federation, Kaliningrad, 236038; Moscow, 119991
I. O. Mazunin
Institute of Living Systems
Email: yukon@sifibr.irk.ru
Russian Federation, Kaliningrad, 236038