Activation of Yeast Mitochondrial Translation: Who Is in Charge?
- Authors: Derbikova K.S.1, Levitsky S.A.1, Chicherin I.V.1, Vinogradova E.N.1, Kamenski P.A.1,2
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Affiliations:
- Faculty of Biology
- Institute of Living Systems
- Issue: Vol 83, No 2 (2018)
- Pages: 87-97
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151592
- DOI: https://doi.org/10.1134/S0006297918020013
- ID: 151592
Cite item
Abstract
Mitochondrial genome has undergone significant reduction in a course of evolution; however, it still contains a set of protein-encoding genes and requires translational machinery for their expression. Mitochondrial translation is of the prokaryotic type with several remarkable differences. This review is dedicated to one of the most puzzling features of mitochondrial protein synthesis, namely, the system of translational activators, i.e., proteins that specifically regulate translation of individual mitochondrial mRNAs and couple protein biosynthesis with the assembly of mitochondrial respiratory chain complexes. The review does not claim to be a comprehensive analysis of all published data; it is rather focused on the idea of the “core component” of the translational activator system.
Keywords
About the authors
K. S. Derbikova
Faculty of Biology
Email: peter@protein.bio.msu.ru
Russian Federation, Moscow, 119991
S. A. Levitsky
Faculty of Biology
Email: peter@protein.bio.msu.ru
Russian Federation, Moscow, 119991
I. V. Chicherin
Faculty of Biology
Email: peter@protein.bio.msu.ru
Russian Federation, Moscow, 119991
E. N. Vinogradova
Faculty of Biology
Email: peter@protein.bio.msu.ru
Russian Federation, Moscow, 119991
P. A. Kamenski
Faculty of Biology; Institute of Living Systems
Author for correspondence.
Email: peter@protein.bio.msu.ru
Russian Federation, Moscow, 119991; Kaliningrad, 236038