Three-finger proteins from the Ly6/uPAR family: Functional diversity within one structural motif
- Authors: Vasilyeva N.A.1,2,3, Loktyushov E.V.1,2, Bychkov M.L.2, Shenkarev Z.O.2, Lyukmanova E.N.1,2
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Affiliations:
- Faculty of Biology
- Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Higher Nervous Activity and Neurophysiology
- Issue: Vol 82, No 13 (2017)
- Pages: 1702-1715
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151557
- DOI: https://doi.org/10.1134/S0006297917130090
- ID: 151557
Cite item
Abstract
The discovery in higher animals of proteins from the Ly6/uPAR family, which have structural homology with snake “three-finger” neurotoxins, has generated great interest in these molecules and their role in the functioning of the organism. These proteins have been found in the nervous, immune, endocrine, and reproductive systems of mammals. There are two types of the Ly6/uPAR proteins: those associated with the cell membrane by GPI-anchor and secreted ones. For some of them (Lynx1, SLURP-1, SLURP-2, Lypd6), as well as for snake α-neurotoxins, the target of action is nico- tinic acetylcholine receptors, which are widely represented in the central and peripheral nervous systems, and in many other tissues, including epithelial cells and the immune system. However, the targets of most proteins from the Ly6/uPAR family and the mechanism of their action remain unknown. This review presents data on the structural and functional properties of the Ly6/uPAR proteins, which reveal a variety of functions within a single structural motif.
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About the authors
N. A. Vasilyeva
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry; Institute of Higher Nervous Activity and Neurophysiology
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997; Moscow, 117485
E. V. Loktyushov
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997
M. L. Bychkov
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 117997
Z. O. Shenkarev
Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 117997
E. N. Lyukmanova
Faculty of Biology; Shemyakin−Ovchinnikov Institute of Bioorganic Chemistry
Author for correspondence.
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 119991; Moscow, 117997
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